功能性材料修饰的纳米粒在口服给药系统中的应用  

Applications of Functional Polymer Modified Nanoparticles in the Oral Drug Delivery System

作　　者：刘湾[1] 杨世林[1] 金一 奉建芳 涂亮星 LIU Wan;YANG Shilin;JIN Yi;FENG Jianfang;TU Liangxing(National Engineering Research Center for Manufacturing Technology of Chinese Medicine Solid Preparations,Jiangxi University of Chinese Medicine,Nanchang 330004;School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200)

机构地区：[1]江西中医药大学中药固体制剂制造技术国家工程中心,江西南昌330004 [2]广西中医药大学药学院,广西南宁530200

出　　处：《中国医药工业杂志》2023年第1期48-56,共9页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金项目(81960717)。

摘　　要：药物纳米粒常被用于改善口服给药的生物利用度,但因胃肠道中的黏液层、P糖蛋白(P-gp)外排及紧密连接等生理屏障,纳米粒改善口服药物生物利用度的程度有限。功能性材料修饰的纳米粒因其功能性、可修饰和多样性成为了口服药物载体策略的研究热点。该研究简述了限制药物生物利用度的因素,重点总结了通过改善药物理化性质和克服生物屏障改善药物生物利用度的功能性纳米材料,以期为难溶性药物的载药策略研究提供参考和文献支持。Drug nanoparticles are often used to improve the bioavailability of oral drug delivery. However, due to physiological barriers such as mucus layer, P-glycoprotein(P-gp) efflux, and tight junctions in the gastrointestinal tract, the improvement of bioavailability of oral drugs by nanoparticles is limited. Nanoparticles modified with functional materials have become a research hotspot for oral drug delivery strategies due to their functionality, modifiability, and diversity.This study briefly describes the factors that limit the bioavailability of drugs and focuses on the summary of functional nanomaterials that enhance drug bioavailability by improving drug physicochemical properties and overcoming biological barriers to provide references and literature support for the study of drug loading strategies for poorly soluble drugs.

关 键 词：功能性材料 表面修饰 纳米粒 难溶性药物 口服吸收 

分 类 号：R944.9[医药卫生—药剂学]