应用助溶剂提高难溶性药物溶解度的研究进展  

Research Progress of Improving Solubility of Poorly Soluble Drugs with Hydrotropes

作　　者：王璐 郭美瑜 齐晓丹 WANG Lu;GUO Meiyu;QI Xiaodan(Dept.of Pharmaceutics,School of Pharmacy,Hebei Medical University,Shijiazhuang 050017)

机构地区：[1]河北医科大学药学院药剂学教研室,河北石家庄050017

出　　处：《中国医药工业杂志》2023年第1期57-62,共6页Chinese Journal of Pharmaceuticals

摘　　要：目前超过70%的候选药物由于溶解度低而应用受限。添加助溶剂是提高难溶性药物溶解度的常用方法之一。助溶剂不易燃、易获得、环境友好、回收快,在提高难溶性药物溶解度方面的应用越来越广泛。然而,许多助溶剂的助溶机制尚不明确,对助溶机制的探索是当前研究的热点之一。该研究简述了助溶剂的分类,重点介绍助溶机制,包括助溶剂的自缔合、助溶剂与溶质的络合、水结构的改变等,以期为应用助溶剂提高难溶性药物溶解度提供理论参考。At present, the clinical applications of over 70% of drug candidates are limited due to their poor solubility. Adding hydrotropes is one of the common methods to improve the solubility of poorly soluble drugs.Hydrotropes are nonflammable, easily accessible, eco-friendly, and rapidly recyclable, so the applications of hydrotropes in improving the solubility of poorly soluble drugs are more and more extensive. However, the solubilization mechanisms of many hydrotropes are still unclear, and exploration of solubilization mechanisms is one of the current research hotspots.This paper introduces the classifications of hydrotropes, and focuses on the mechanisms of hydrotropes, including the molecular self-assembly of hydrotropes, the complexation of hydrotropes with solute molecules, and water structure changes, in order to provide theoretical references for applying hydrotropes to improve the solubility of poorly soluble drugs.

关 键 词：助溶剂 难溶性药物 溶解度 增溶作用 

分 类 号：O645.12[理学—物理化学]