生物型金属有机骨架MOF-79的合成、表征及载槲皮素药物性能的研究  

Synthesis and Characterization of Biological Metal-organic Frameworks and Study on Its Quercetin-loading Properties

作　　者：陈进 林令琪 钱昆 赵亮 CHEN Jin;LIN Lingqi;QIAN Kun;ZHAO Liang(College of Pharmacy,Jinzhou Medical University,Jinzhou 121000;College of Public Foundation,Jinzhou Medical University,Jinzhou 121000)

机构地区：[1]锦州医科大学药学院,辽宁锦州121000 [2]锦州医科大学公共基础学院,辽宁锦州121000

出　　处：《中国医药工业杂志》2023年第1期75-84,共10页Chinese Journal of Pharmaceuticals

基　　金：辽宁省教育厅课题(JYTJCZR2020067)。

摘　　要：该研究通过搅拌加热的方法首次成功制备了以腺嘌呤为有机配体、金属钛为核心的生物型金属有机骨架(MOF),Ti-MOF-79,并以槲皮素(1)为药物模型对Ti-MOF-79的载药、释药性能进行研究。通过扫描电镜(SEM)、X射线衍射(XRD)、差示扫描量热(DSC)、X射线光电子能谱(XPS)、红外光谱(IR)、紫外光谱(UV)和细胞毒性试验等方法对该材料和载药复合物进行表征,并计算了载药量及累积释放率。结果表明Ti-MOF-79是一种规则的圆柱体形晶体,具有多孔结构,载药量为(28.83±8.35)%,在体外具有一定的缓释作用,且无明显的细胞毒性,提示MOF有望成为新型载体材料。The biological metal-organic framework(MOF)Ti-MOF-79 with adenine as an organic ligand and Ti as a metal core was synthesized under hydrothermal conditions.Quercetin(1)was used as a drug model to investigate the drug loading and release performance of Ti-MOF-79.The material and the drug-loaded complexes were characterized through transmission electron microscopy(SEM),X-ray diffractometry(XRD),differential scanning calorimetry(DSC),X-ray photoelectron spectroscopy(XPS),infrared spectroscopy(IR),ultraviolet spectroscopy(UV)and cytotoxicity test,and the drug loading and cumulative release rates were calculated.The results showed that Ti-MOF-79 was a regular long cylindrical crystal with porous structure.The results of in vitro experiments showed that the complexes with drug loading of(28.83±8.35)%had a sustained-release profile and had no obvious cytotoxicity,which indicated that MOF could become a novel carrier material.

关 键 词：生物型金属有机骨架 槲皮素 药物递送 药物载体 

分 类 号：R945[医药卫生—微生物与生化药学]