成像流式细胞术在辐射生物剂量学指标自动分析中的研究进展  

Research progress of imaging flow cytometry in automatic analysis of radiation biodosimetric indicators

作　　者：刘晓明[1] 程娇 崔双双 党旭红[1] 董娟聪[1] LIU Xiaoming;CHENG Jiao;CUI Shuangshuang;DANG Xuhong;DONG Juancong(China Institute of Radiation Protection,Taiyuan 030006 China)

机构地区：[1]中国辐射防护研究院,山西太原030006

出　　处：《中国辐射卫生》2023年第1期62-65,共4页Chinese Journal of Radiological Health

摘　　要：大规模核与辐射事故及核恐怖袭击均易造成大量人员受照,急需建立快速、高通量的生物剂量检测分析技术,进行人员的快速分类诊断,指导应急管理。成像流式细胞术(IFC)兼具传统流式细胞术的高通量优势及显微镜的灵敏度和特异性,在快速、自动化、高通量的生物剂量估算技术研发中具有很好的应用前景。本文综述了IFC在生物剂量测定技术研发中的应用进展,为用于大规模核与辐射事故的生物剂量估算检测装备的研发提供借鉴。A large number of people would be exposed to irradiation in large-scale nuclear and radiation accidents or nuclear terrorist attacks.Therefore,it is urgent to establish rapid and high-throughput biodosimetry for in triage,providing a basis for emergency management.Imaging flow cytometry(IFC) possesses the high through put advantages of traditional flow cytometry and the sensitivity and specificity of microscope,and has a good application prospect in the research and development of rapid,automated,and high-throughput biological dose estimation technology.This article reviews the application progress of IFC in biodosimetry,and provides a reference for the development of biological dose estimation and detection equipment for large-scale nuclear and radiation accidents.

关 键 词：生物剂量估算 成像流式细胞术 自动化 核应急 

分 类 号：X591[环境科学与工程—环境工程]