正电子发射断层扫描/计算机断层扫描(PET/CT)成像在肿瘤筛查中的应用进展  

Progress in application of positron emission tomography/computed tomography (PET/CT) imaging in tumor screening

作　　者：陆晓骞 宗凌燕[2] 沈琪 LU Xiaoqian;ZONG Lingyan;SHEN Qi(Department of Medical Devices,Changzhou Second People’s Hospital Affiliated to Nanjing Medical University,Changzhou 213001 China;Department of Equipment and Material Purchase and Supervision,Changzhou Municipal First People’s Hospital,Changzhou 213004 China)

机构地区：[1]南京医科大学附属常州第二人民医院医学装备科,江苏常州213001 [2]常州市第一人民医院装备物资采管处,江苏常州213004

出　　处：《中国辐射卫生》2023年第1期66-69,74,共5页Chinese Journal of Radiological Health

摘　　要：我国是世界癌症发病最多的国家,筛查可以实现肿瘤早期诊断、改善患者预后、提高生存质量、降低死亡率。正电子发射断层扫描/计算机断层扫描(PET/CT)提供的代谢信息有助于肿瘤筛查初始分期、治疗计划、反应评估,并在较小程度上可用于肿瘤的随访;PET/CT成像在放射治疗中的渐进式整合在肿瘤间和肿瘤内恶性病变的生物异质性中具有其基本原理,需要单独调整辐射剂量以获得癌症患者的有效局部肿瘤控制;PET/CT提供有关肿瘤病变的生物学特征(如代谢、缺氧和增殖)的信息,可以识别放射性耐药区域并利用这些信息来优化治疗计划,PET/CT减少了肿瘤部位解剖学描绘的不确定性和可变性。本文主要就目前常见肿瘤在PET/CT研究中的应用进展进行综述。Worldwide,the incidence of cancer is greatest in China.Tumor screening is effective to achieve early diagnosis,improve prognosis,increase the quality of life,and reduce mortality among cancer patients.Positron emission tomography/computed tomography(PET/CT) imaging provides metabolic data to support initial staging,treatment planning,and response evaluation in tumor screening,as well as tumor follow-up.The progressive integration of PET/CT imaging in radiotherapy has its basic principle in the biological heterogeneity of inter-and intra-tumor malignant lesions,and the radiation dose is required to be adjusted to achieve effective local tumor control among cancer patients.In addition,PET/CT imaging provides data on the biological features of tumor lesions,such as metabolism,hypoxia,and proliferation,which is useful to identify radiation-resistant regions and optimize treatment plans.These data are effective to reduce the uncertainty and variability in the anatomic description of tumor sites.This review summarizes the application of PET/CT imaging in common tumors.

关 键 词：正电子发射断层扫描/计算机断层扫描 肿瘤筛查 放射治疗 

分 类 号：R816[医药卫生—放射医学]