Objection non-responsive! How maternal immune activation in pregnancy weakens subsequent microglial immune response  

作　　者：Thomas Blank Marco Prinz 

机构地区：[1]Institute of Neuropathology,Faculty of Medicine,University of Freiburg,Freiburg,Germany [2]Center for NeuroModulation,Faculty of Medicine,University of Freiburg,Freiburg,Germany [3]Signalling Research Centers BIOSS and CIBSS,University of Freiburg,Freiburg,Germany

出　　处：《Cell Research》2023年第3期193-194,共2页细胞研究（英文版）

摘　　要：Virus-like immunological stress during pregnancy diminishes subsequent microglia reactivity,elevating astrocyte inflam-matory state and reducing synaptic activity in medium spiny neurons of the ventral striatum.The developing immune system and central nervous system(CNS)in the fetus are especially sensitive to both external and endogenous signals.Early immune system activation has been proposed to cause lifetime changes,and additional evidence suggests that immunological dysregulation in the developing brain may play a role in neurodevelopmental disorders such as autism or schizophrenia by affecting the primary parenchymal immune cells of the CNS called microglia.

关 键 词：PREGNANCY FETUS endogenous 

分 类 号：R714[医药卫生—妇产科学]