快速绿色合成萘基四氢异喹啉衍生物  

A Rapid and Green route for the preparation of Naphthalyl Tetrahydroisoquinoline Derivative

作　　者：李彦博 况政 王渝 刘芳[1] 李和平[1] LI Yan-bo;KUANG Zheng;WANG Yu;LIU Fang;LI He-ping(School of Chemistry and Chemical Engineering,Changsha University of Science&Technology,Changsha 410114,China)

机构地区：[1]长沙理工大学化学化工学院,湖南长沙410114

出　　处：《精细化工中间体》2023年第1期26-29,53,共5页Fine Chemical Intermediates

基　　金：湖南省自然科学基金(2019JJ40295);2022年度湖南省大学生创新创业训练计划项目。

摘　　要：以萘甲醛、丙二腈和1-乙基哌啶-4-酮为原料,通过室温研磨2~5 min实现三组分的加成/环合过程,合成了新型萘基四氢异喹啉衍生物。产物结构经高分辨质谱、核磁共振氢谱、核磁共振碳谱、红外光谱和紫外-可见吸收光谱等表征确证。该方法绿色化学特点显著,具有工业化生产潜力。A novel naphthalenyl tetrahydroisoquinoline derivative was synthesized by addition/cyclozation of naphthalene formaldehyde,malonitrile and 1-ethylpiperidine-4-ketone by grinding 2~5 min at room temperature.The chemical structures were characterized by MS,^(1)H NMR,^(13)C NMR,IR and UV-vis.This method has remarkable green chemical characteristics and is very attractive for industrial production.

关 键 词：四氢异喹啉 绿色合成 无催化剂 无溶剂 

分 类 号：O622.5[理学—有机化学]