吡拉西坦合成工艺的改进  

Synthesis of Piracetam

作　　者：庹仪敏 向莉蓉 荆一丹 肖子丹[1] TUO Yi-min;XIANG Li-rong;JING Yi-dan;XIAO Zi-dan(School of Chemistry and Chemical Engineering,Changsha University of Science&Technology,Changsha 410000,China)

机构地区：[1]长沙理工大学化学化工学院,湖南长沙410000

出　　处：《精细化工中间体》2023年第1期39-41,共3页Fine Chemical Intermediates

摘　　要：以α-吡咯烷酮为起始原料,经与甲醇钠反应得到吡咯烷酮钠盐(2),再与氯乙酸甲酯缩合得到吡咯烷酮乙酸甲酯(3),最后经过氨解反应得吡拉西坦(1)。该制备方法三废少、污染小、效率高、收率高,具有工业化应用前景。Using 2-pyrrolidone as starting material,pyrrolidone sodium salt(2)was prepared by substitution re⁃action;methyl pyrrolidone acetate(3)was obtained by the condensation reaction of 2;finally piracetam(1)was obtained by the ammonolysis reaction of 3.This preparation method has the advantages of less waste,less pollu⁃tion,high efficiency and high yield,and has the prospect of industrial application.

关 键 词：吡拉西坦 乙酰胺吡咯烷酮 Α-吡咯烷酮 吡咯烷酮乙酸甲酯 

分 类 号：TQ460.31[化学工程—制药化工]