肺巨噬细胞衰老在慢性阻塞性肺疾病发病中的作用  

The role of lung macrophages senescence in the pathogenesis of chronic obstructive pulmonary disease

作　　者：李鑫[1] 刘晓菊[2] Li Xin;Liu Xiaoju(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Gerontal Respiratory Medicine,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院老年呼吸科,兰州730000

出　　处：《国际呼吸杂志》2023年第2期125-131,共7页International Journal of Respiration

基　　金：国家自然科学基金(82260010);甘肃省科技计划项目-创新基地和人才计划(20JR10FA666)。

摘　　要：慢性阻塞性肺疾病(COPD)是一种与衰老密切相关的疾病。肺巨噬细胞(LMs)是重要的固有免疫和适应性免疫效应细胞,也是COPD气道炎症的主要细胞之一,在COPD发病中发挥关键作用。本文详细介绍了LMs在衰老过程中发生的表型和功能等变化,包括吞噬下降、衰老相关标志物增加、炎症细胞因子生成增加等。以期了解LMs的衰老在COPD发生、发展中的作用,探寻抗衰老治疗是否可成为COPD治疗的新思路。Chronic obstructive pulmonary disease(COPD)is a disease closely related to aging.Lung macrophages(LMs)are important innate and adaptive immune effector cells.LMs are also one of the main cell subsets in COPD airway inflammation,which play a key role in the pathogenesis of COPD.In this review,we detailed the phenotypic and functional changes in LMs during cell senescence,including decreased phagocytosis,increased aging-related markers,and increased production of inflammatory cytokines.This study aims to elucidate the role of LMs senescence in the occurrence and development of COPD,and to explore the potential of anti-aging therapy for COPD.

关 键 词：肺疾病 慢性阻塞性 巨噬细胞 肺泡 衰老 

分 类 号：R563.9[医药卫生—呼吸系统]