机械通气相关性肺损伤生物伤发生机制的研究进展  

Research progress on mechanism of biotrauma caused by ventilation-induced lung injury

作　　者：练思雨 周垒垒 蒋文青 张先明 Lian Siyu;Zhou Leilei;Jiang Wenqing;Zhang Xianming(Department of Respiratory and Critical Care Medicine,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China;Department of Respiratory Medicine,the Second People's Hospital of Guizhou Province,Guiyang 550004,Guizhou,China)

机构地区：[1]贵州医科大学附属医院呼吸与危重症医学科,贵阳550004 [2]贵州省第二人民医院呼吸内科,贵阳550004

出　　处：《中华危重病急救医学》2023年第2期217-220,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金(81660018);贵州省科技计划项目(2021-061);贵州省卫生健康委科学技术基金项目(gzwkj2021-090)。

摘　　要：机械通气作为治疗急性呼吸衰竭患者的一种高级生命支持手段,在稳定呼吸功能的同时,也作为损伤因素诱导或加重肺损伤,即机械通气相关性肺损伤(VILI)。VILI可能存在一种更微妙的损伤形式,这种损伤形式被称为"生物伤"。目前VILI生物伤的发生机制尚不明确。因此,本文从炎症反应、氧化应激、补体激活、血气屏障等方面总结了VILI生物伤的发生机制,以期为临床制定VILI生物伤的防治策略提供参考。Mechanical ventilation is an advanced life support treatment for patients with acute respiratory failure.While stabilizing respiratory function,it also acts as an injury factor to exacerbate or lead to lung injury,that is,ventilation-induced lung injury(VILI).There may be a more subtle form of damage to VILI known as"biotrauma".However,the mechanism of biotrauma in VILI is still unclear.This article intends to review the mechanism of biotrauma of VILI from the aspects of inflammatory response,oxidative stress and complement activation,in order to provide a new strategy for clinical prevention and treatment of biotrauma caused by VILI.

关 键 词：机械通气相关性肺损伤 生物伤 炎症反应 氧化应激 补体激活 血气屏障 

分 类 号：R563.8[医药卫生—呼吸系统]