寄生虫病表位疫苗研究进展  

Advances in parasite epitope vaccine research

作　　者：吴晓莹 胡媛 曹建平 WU Xiaoying;HU Yuan;CAO Jianping(National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research),NHC Key Laboratory of Parasite and Vector Biology,National Health Commission,WHO Collaborating Centre for Tropical Diseases,National Center for International Research on Tropical Diseases,Shanghai 200025,China)

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心),国家卫生健康委员会寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,国家热带病国际联合研究中心,上海200025

出　　处：《中国寄生虫学与寄生虫病杂志》2023年第1期98-102,107,共6页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：上海市自然科学基金(19ZR1462600);国家自然科学基金面上项目(81971969)。

摘　　要：寄生虫病不仅严重威胁人类健康,而且也给畜牧业造成巨大经济损失。目前研制安全有效的疫苗是寄生虫病预防控制的策略之一。表位疫苗具有特异性高、安全性好、设计灵活、易于生产和储存等优点,可同时诱导机体体液免疫和细胞免疫。近年来寄生虫病表位疫苗研究取得了较大进展,本文对寄生虫病表位设计及相关疫苗研究进展进行综述,旨在为高效疫苗的研制提供参考。Parasitic diseases not only seriously threaten human health,but also cause huge economic losses to animal husbandry.At present,developing safe and effective vaccines is one of the strategies for the prevention and control of parasitic diseases.Epitope vaccine has the advantages of high specificity,safety,flexible design,easy production and storage,and can induce humoral and cellular immunity simultaneously.In recent years,great progress had been made in the epitope vaccines for parasitic diseases.This paper have reviewed the recent advances of vaccine epitope design and related vaccine research in parasitic diseases,in order to provide reference for the further development of effective vaccines.

关 键 词：寄生虫病 表位疫苗 表位设计 合成肽疫苗 

分 类 号：R53[医药卫生—内科学]