促凋亡蛋白BAK的功能及在病毒感染中作用的研究进展  

Research Progress on the Function of Pro-apoptotic Protein BAK and Its Role in Virus Infection

作　　者：徐炜民 邓鑫 伍锐 XU Wei-min;DENG Xin;WU Rui(Research Center of Swine Diseases,College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 610000,China)

机构地区：[1]四川农业大学动物医学院猪病研究中心,成都610000

出　　处：《中国生物工程杂志》2023年第2期130-140,共11页China Biotechnology

基　　金：国家重点研发计划(2021YFD1100206)资助项目。

摘　　要：BAK蛋白从属于BCL-2家族,是细胞凋亡途径中的关键蛋白。BAK蛋白在凋亡信号的刺激下被激活,并在线粒体上集聚成簇后诱导细胞色素c等促凋亡物质释放,通过caspase级联反应放大凋亡信号,最终诱导细胞死亡。目前的BAK研究普遍用于针对癌细胞凋亡逃逸及病毒对机体细胞免疫的逃逸过程,而病毒等病原体与BAK之间的作用机制、影响胞内凋亡和炎症通路的激活以及炎性因子活化的研究较少。因此对BAK蛋白结构、功能和BAK可能介导的相关通路进行介绍,并对其在病毒感染研究中的作用进展进行了分析,以期为促凋亡蛋白BAK在病毒感染中作用的深入研究提供一些理论基础。BAK protein,a member of the BCL-2 family,is a key protein in the apoptosis pathway.It is activated under the stimulation of apoptotic signals,and after clustering on mitochondria,induces the release of cytochrome c and other pro-apoptotic substances,amplifies apoptosis signals through caspase cascade reaction,and finally promotes cell death.At present,the role of BAK in the apoptosis escape of cancer cells and the activation of intracellular inflammatory response has been confirmed,but the mechanism of action between viruses and other pathogens and BAK,the activation process of intracellular apoptosis and inflammatory pathways are less studied.Therefore,in this paper,the structure and function of BAK protein and the related pathways mediated by BAK are introduced,and the progress of its role in the study of virus infection is analyzed,in order to provide some theoretical basis for the in-depth study of the pro-apoptotic protein BAK in virus infection.

关 键 词：促凋亡蛋白 BAK 细胞凋亡 BCL蛋白家族 病毒感染 

分 类 号：Q946.[生物学—植物学]