短刺法合柴胡桂枝龙骨牡蛎汤治疗退行性脊椎病伴抑郁患者的疗效  

Effect of Short Needling Combined with Chaihu Guizhi Longgu Muli Decoction(柴胡桂枝龙骨牡蛎汤)on Degenerative Spondylitis with Depression

作　　者：董琦[1] 李镰行 黄继升 DONG Qi;LI Lianxing;HUANG Jisheng(Department of Acupuncture and Moxibustion,Tianshui Hospital of Integrated Traditional Chinese and Western Medicine,Tianshui 741020,China)

机构地区：[1]天水市中西医结合医院针灸科,甘肃天水741020

出　　处：《山东中医杂志》2023年第4期363-368,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：甘肃省自然基金计划项目(编号:1610RJZA075);天水市科技支撑计划项目(编号:2021-SHFZKJK-9372)。

摘　　要：目的:观察短刺法合柴胡桂枝龙骨牡蛎汤治疗退行性脊椎病伴抑郁患者的疗效。方法:选取2018年1月至2020年4月于天水市中西医结合医院收治的120例退行性脊椎病伴抑郁患者,采用随机数字表法分为4组(A组、B组、C组、D组),各30例。A组采用常规西医治疗,B组采用常规西医联合短刺法治疗,C组采用常规西医联合柴胡桂枝龙骨牡蛎汤治疗,D组采用常规西医联合短刺法和柴胡桂枝龙骨牡蛎汤治疗,疗程均为3个月。观察4组治疗前后抑郁情绪变化和关节疼痛症状变化、临床疗效、血清5-羟色胺(5-HT)水平及不良反应发生率。结果:治疗后4组抑郁自评量表(SDS)评分、关节疼痛评分均较治疗前下降(P<0.05),血清5-HT水平较治疗前提高(P<0.05);治疗后D组SDS评分和关节疼痛评分均低于A组、B组和C组(P<0.05),血清5-HT水平高于A组、B组和C组(P<0.05);治疗后C组SDS评分低于A组和B组(P<0.05),血清5-HT水平高于A组和B组(P<0.05);A组和B组SDS评分和血清5-HT水平比较差异均无统计学意义(P>0.05);治疗后B组和C组关节疼痛评分均低于A组(P<0.05),B组和C组治疗后关节疼痛评分比较差异均无统计学意义(P>0.05);4组抑郁治疗效果和退行性脊椎病治疗效果等级分布差异均有统计学意义(P<0.05),D组抑郁总有效率和退行性脊椎病总有效率均高于A组(P<0.01);4组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:短刺法合柴胡桂枝龙骨牡蛎汤治疗退行性脊椎病伴抑郁效果确切,二者联合可有效缓解患者抑郁情绪,减轻患者关节疼痛程度,且安全性高。Objective:To observe the curative effect of short needling combined with Chaihu Guizhi Longgu Muli Decoction(柴胡桂枝龙骨牡蛎汤)on degenerative spondylitis with depression.Methods:One hundred and twenty degenerative spondylitis patients with depression in Tianshui Hospital of Integrated Traditional Chinese and Western Medicine from January 2018 to April 2020 were selected and randomly divided into 4 groups(group A,group B,group C and group D),30 patients in each group.Group A was treated with conventional western medicine,group B was treated with conventional western medicine and short needling,and group C was treated with conventional western medicine and Chaihu Guizhi Longgu Muli Decoction,group D was treated with conventional western medicine and short needling and Chaihu Guizhi Longgu Muli Decoction.All the four groups were treated for 3 months.The changes of depression and joint pain symptoms before and after treatment,clinical efficacy,serum levels of 5-hydroxytryptamine(5-HT)before and after treatment,and incidence of adverse reactions were observed.Results:After treatment,the scores of self-rating depression scale(SDS)and joint pain scores of the four groups were lower than before treatment(P<0.05),and serum levels of 5-HT in the four groups were higher than before treatment(P<0.05).After treatment,the SDS and joint pain scores were lower in group D than in group A,group B and group C(P<0.05),and the serum 5-HT level in group D was higher than those in group A,group B and group C(P<0.05).After treatment,the SDS score in group C was lower than that in group B and group A(P<0.05),and the serum level of 5-HT in group C was higher than that in group A and group B(P<0.05).There were no significant differences in SDS scores and serum level of 5-HT between group A and group B(P>0.05).After treatment,the joint pain score in group A was higher than that in group B and group C(P<0.05).There was no significant difference in joint pain score between group B and group C after treatment(P>0.05).There were sign

关 键 词：短刺法 柴胡桂枝龙骨牡蛎汤 抑郁 退行性脊椎病 5-羟色胺 

分 类 号：R681.5[医药卫生—骨科学]