地龙蛋白治疗血管内皮损伤所致阴茎勃起功能障碍作用机制研究进展  

Research progress on the action mechanism of protein from earthworm in the treatment of erectile dysfunetion caused by vascular endothelial injury

作　　者：张爱平 刘黎明 冀小卫 李应东 赵信科 邢喜平 ZHANG Aiping;LIU Liming;JI Xiaowei;LI Yingdong;ZHAO Xinke;XING Xiping(College of Integrated Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou,Gansu,730101,China;Department of Urology(Andrology),Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou,Gansu,730020,China)

机构地区：[1]甘肃中医药大学中西医结合学院,甘肃兰州730101 [2]甘肃中医药大学附属医院泌尿外科/男科,甘肃兰州730020

出　　处：《甘肃中医药大学学报》2023年第1期101-105,共5页Journal of Gansu University of Chinese Medicine

基　　金：甘肃省中医药防治慢性病重点实验室开放基金(GSMBKY2015-13);2021年甘肃省重点人才项目(202117);甘肃中医药大学附属医院院内课题(gzfy-2019-07);甘肃省中医药管理局基金项目(GZKP-2021-18)。

摘　　要：查阅相关文献,从抗炎、抗氧化、抗凝、降脂、降压等5个方面概述地龙蛋白保护血管内皮,从而治疗血管内皮损伤引起的阴茎勃起功能障碍的作用机制。目前对于地龙蛋白中具体成分的作用尚未明确,还需进一步研究。今后可通过提高地龙蛋白提纯工艺,建立血管内皮损伤性阴茎勃起功能障碍大鼠模型,探究地龙蛋白不同成分治疗血管内皮损伤性阴茎勃起功能障碍的具体作用机制,明确其作用靶点,从而为治疗阴茎勃起功能障碍提供理论依据,拓展新思路。A review of relevant literature was conducted to outline the action mechanism of protein from earthworm in protecting vascular endothelium and thus treating erectile dysfunction(ED)caused by vascular endothelial injury from five aspects,including anti-inflammatory,antioxidant,anticoagulant,lipid-lowering and antihypertensive.The effects of the specific components in the protein from earthworm are not yet clear and further research is needed.In the future,by improving the purification process of protein from earthworm and establishing a rat model of ED due to vascular endothelial injury,the specific action mechanism of different components of protein from earthworm in treating ED due to vascular endothelial injury can be investigated and its target of action can be clarified,so as to provide a theoretical basis and expand new ideas for the treatment of ED.

关 键 词：阴茎勃起功能障碍 地龙蛋白 作用机制 综述 

分 类 号：R698.1[医药卫生—泌尿科学]