Impact of indoor ventilation efficiency on acetone inhalation exposure concentration and tissue dose in respiratory tract  

作　　者：Cong Li Sung-Jun Yoo Kazuhide Ito 

机构地区：[1]College of Ocean and Civil Engineering,Dalian Ocean University,Dalian 116023,China [2]Faculty of Engineering Sciences,Kyushu University,Fukuoka,816-8580,Japan

出　　处：《Building Simulation》2023年第3期427-441,共15页建筑模拟（英文）

基　　金：partially funded by the Japan Science and Technology(JST),CREST Japan(No.JP 20356547);the Japan Society for the Promotion of Science(JSPS)Grants-in-Aid for Scientific Research(KAKENHI)(No.JP 22H00237 and No.JP 20KK0099);Health Labour Sciences Research Grant(No.JP 21KD2002);MEXT as“Program for Promoting Researches on the Supercomputer Fugaku”(No.JPMXP1020210316).

摘　　要：A significant feature of the indoor environment is the heterogeneity of airflow and pollutant distributions,which are primarily dependent on ventilation systems.In the case of short-and high-concentration exposures to hazardous chemical pollutants,it may be necessary to precisely determine the concentration in the breathing zone or,more directly,the inhalation exposure concentration in the respiratory tract,rather than the representative room average concentration in an indoor environment,because of the non-uniformity of pollutant concentration distributions.In this study,we developed a computer-simulated person with a detailed respiratory system to predict inhalation exposure concentration and inhalation dose via transient breathing and reported a demonstrative numerical simulation for analyzing acetone concentration distributions in a simplified model room.Our numerical analysis revealed that the ventilation efficiency distribution in a room could change significantly by changing the design of the ventilation system,and that the inhalation exposure concentration estimated by a computer-simulated person could differ from the representative concentration,such as perfect-mixing or volume-averaged acetone concentration,by a factor of two or more.

关 键 词：computational fluid dynamics computer simulated person inhalation exposure numerical respiratory tract physiologically based pharmacokinetics tissue dose 

分 类 号：R56[医药卫生—呼吸系统] X51[医药卫生—内科学]