吡啶硼酸催化己内酯开环聚合的研究  

Study on Caprolactone Ring-opening Polymerization with Pyridine Boric Acid as An Organic Catalyst

作　　者：肖镇 徐俊熙 许进宝 XIAO Zhen;XU Jun-xi;XU Jin-bao(School of Materials and Energy,Guangdong University of Technology,Guangdong Guangzhou 510006;Foshan University,Guangdong Foshan 528225,China)

机构地区：[1]广东工业大学材料与能源学院,广东广州510006 [2]佛山科学技术学院,广东佛山528225

出　　处：《广州化工》2023年第2期126-129,共4页GuangZhou Chemical Industry

摘　　要：聚己内酯(PCL)具有良好的生物相容性和生物可降解性,因此在生物医学、食品包装和组织工程领域得到广泛应用,开环聚合是合成PCL的主要方式。4-吡啶硼酸(4-PBA)作为催化剂,苯甲醇作为引发剂,对ε-己内酯(ε-CL)进行本体开环聚合反应得到PCL,探究了4-PBA催化ε-CL开环聚合适宜的反应条件,当反应温度为150℃、催化剂含量为2%时催化活性最高。对比了不同结构吡啶硼酸的催化活性,研究表明2-PBA>3-PBA>4-PBA>5-QBA>4-QBA:邻位以及间位结构的2-PBA和3-PBA在150℃下反应12 h的转化率较高,分别能够达到98.02%、86.18%;4-PBA在150℃下反应12 h的转化率为43.66%,延长反应时间至24 h转化率能达到94.81%,将吡啶基替换成联苯结构的喹啉基团,催化性能并没有得到明显提升。动力学研究表明转化率与时间呈线性关系,分子量随反应时间增大而增大。Polycaprolactone(PCL)has good biocompatibility and biodegradability,so it is widely used in biomedical,food packaging and tissue engineering fields,and ring-opening polymerization is the main way to synthesize PCL.4-pyridineboronic acid(4-PBA)was used as a catalyst and benzyl alcohol was used as an initiator for the native ring-opening polymerization reaction ofε-caprolactone(ε-CL)to obtain PCL,and the suitable reaction conditions for 4-PBA-catalyzed ring-opening polymerization ofε-CL were investigated.The suitable reaction conditions for the ring-opening polymerization ofε-CL catalyzed by 4-PBA were investigated,and the highest catalytic activity was obtained at a reaction temperature of 150℃and a catalyst content of 2%.The catalytic activity of different structures of pyridineboronic acid was compared,and the study showed that 2-PBA>3-PBA>4-PBA>5-QBA>4-QBA.The conversion rates of 2-PBA and 3-PBA in the adjacent and interposition structures were higher at 150℃for 12 h,reaching 98.02%and 86.18%,respectively.The conversion rate of 4-PBA at 150℃for 12 h was 43.66%.The catalytic performance was not significantly improved by replacing the pyridine group with the quinoline group of the biphenyl structure.The kinetic study showed that the conversion was linear with time and the molecular weight increased with the increase of reaction time.

关 键 词：吡啶硼酸 有机催化剂 开环聚合 己内酯 

分 类 号：O631.13[理学—高分子化学]