肿瘤坏死因子-α调控骨质疏松症作用机制研究  

Research on the regulating mechanism of tumor necrosis factor-αin osteoporosis

作　　者：袁剑 孔令俊[2] 丁海霞 赵军[2] 王玉泉[2] 王晨亮 邓叶龙 黄晓焱 YUAN Jian;KONG Lingjun;DING Haixia;ZHAO Jun;WANG Yuquan;WANG Chenliang;DENG Yelong;HUANG Xiaoyan(Gansu University of Traditional Chinese Medicine,Lanzhou 7300002,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730005,China;The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050 [3]甘肃中医药大学附属医院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2023年第3期426-430,436,共6页Chinese Journal of Osteoporosis

基　　金：甘肃省自然科学基金项目(20JR10RA360);兰州市人才创新创业项目(2020-RC-55)。

摘　　要：成骨细胞(osteoblast,OB)与破骨细胞(osteoclast,OC)动态平衡调控着骨重塑稳态,其平衡被打破将介导系列骨疾病发生与发展,如骨质疏松症(osteoporosis,OP)、类风湿关节炎(RA)和骨硬化症等。肿瘤坏死因子-α(tumor necrosis factorα,TNF-α)是一种由活化的巨噬细胞/单核细胞产生的炎性细胞因子,是骨吸收增强剂和骨形成抑制剂,可调控骨髓间充质干细胞(bone mesenchymal stemcells,BMSCs)、OB和OC相关信号通路、蛋白及基因表达而减弱BMSCs成骨分化、抑制OB矿化和促进OC活化、增殖与成熟,导致骨形成和吸收之间动态失衡扰乱骨重建而促进OP的进展。因此,笔者通过查阅国内外相关文献资料总结TNF-α在OP中的相关作用机制以期为进一步临床研究提供一定理论依据。The dynamic balance between osteoblasts(OB)and osteoclasts(OC)regulates the homeostasis of bone remodeling.The imbalance between them may mediate the occurrence and development of a series of bone diseases,such as osteoporosis(OP),rheumatoid arthritis(RA),and osteosclerosis.Tumor necrosis factor-α(TNF-α)is an inflammatory cytokine produced by activated macrophages/monocytes.TNF-αis a bone resorption enhancer and bone formation inhibitor.It regulates bone marrow mesenchymal stem cells(BMSCs).The expression of BMSCs,OB,and OC-related signaling pathways,proteins,and genes attenuates osteogenic differentiation of BMSCs,inhibits OB mineralization,and promotes the activation,proliferation,and maturation of OC,leading to the dynamic imbalance between bone formation and resorption,which disturbs bone reconstruction and promotes the progression of OP.Therefore,the author summarizes the relevant mechanism of TNF-αin OP by referring to relevant national and international literature,in order to provide a certain theoretical basis for further clinical research.

关 键 词：骨质疏松 肿瘤坏死因子-Α 骨髓间充质干细胞 成骨细胞 破骨细胞 

分 类 号：R336[医药卫生—人体生理学]