Understanding the multifaceted etiopathogenesis of foot complications in individuals with diabetes  

作　　者：Tatjana Matijević Jasminka Talapko Tomislav Meštrović Marijan Matijević Suzana Erić Ivan Erić IvanaŠkrlec 

机构地区：[1]Department of Dermatology and Venereology,University Hospital Center Osijek,Osijek 31000,Croatia [2]Faculty of Dental Medicine and Health,Josip Juraj Strossmayer University of Osijek,Osijek 31000,Croatia [3]University Centre Varaždin,University North,Varaždin 42000,Croatia [4]Institute for Health Metrics and Evaluation and the Department for Health Metrics Sciences,University of Washington School of Medicine,Seattle,WA 98195,United States [5]Department of Surgery,National Memorial Hospital Vukovar,Vukovar 32000,Croatia [6]Faculty of Medicine,Josip Juraj Strossmayer University of Osijek,Osijek 31000,Croatia [7]Department of Radiotherapy and Oncology,Clinical Hospital Center Osijek,Osijek 31000,Croatia [8]Department of Surgery,Osijek University Hospital Centre,Osijek 31000,Croatia

出　　处：《World Journal of Clinical Cases》2023年第8期1669-1683,共15页世界临床病例杂志

摘　　要：Diabetes mellitus,a chronic disease of metabolism,is characterized by a disordered production or cellular utilization of insulin.Diabetic foot disease,which comprises the spectrum of infection,ulceration,and gangrene,is one of the most severe complications of diabetes and is the most common cause of hospitalization in diabetic patients.The aim of this study is to provide an evidence-based overview of diabetic foot complications.Due to neuropathy,diabetic foot infections can occur in the form of ulcers and minor skin lesions.In patients with diabetic foot ulcers,ischemia and infection are the main causes of non-healing ulcers and amputations.Hyperglycemia compromises the immune system of individuals with diabetes,leading to persistent inflammation and delayed wound healing.In addition,the treatment of diabetic foot infections is challenging due to difficulty in accurate identification of pathogenic microorganisms and the widespread issue of antimicrobial resistance.As a further complicating factor,the warning signs and symptoms of diabetic foot problems can easily be overlooked.Issues associated with diabetic foot complications include peripheral arterial disease and osteomyelitis;accordingly,the risk of these complications in people with diabetes should be assessed annually.Although antimicrobial agents represent the mainstay of treatment for diabetic foot infections,if peripheral arterial disease is present,revascularization should be considered to prevent limb amputation.A multidisciplinary approach to the prevention,diagnosis,and treatment of diabetic patients,including those with foot ulcers,is of the utmost importance to reduce the cost of treatment and avoid major adverse consequences such as amputation.

关 键 词：Diabetic foot Diabetes mellitus Foot ulcer INFECTION Peripheral arterial disease 

分 类 号：R587.2[医药卫生—内分泌]