Diabetic foot ulcer:A comprehensive review of pathophysiology and management modalities  

作　　者：Joel M Raja Miguel A Maturana Sharif Kayali Amir Khouzam Nephertiti Efeovbokhan 

机构地区：[1]Department of Internal Medicine,University of Tennessee Health Science Center,Memphis,TN 38119,United States [2]Department of Cardiology,NEA Baptist Jonesboro,Jonesboro,AR 72401,United States

出　　处：《World Journal of Clinical Cases》2023年第8期1684-1693,共10页世界临床病例杂志

摘　　要：Diabetic foot ulcer (DFU) is a debilitating and severe manifestation ofuncontrolled and prolonged diabetes that presents as ulceration, usually locatedon the plantar aspect of the foot. Approximately 15% of individuals with diabeteswill eventually develop DFU, and 14%-24% of them will require amputation ofthe ulcerated foot due to bone infection or other ulcer-related complications. Thepathologic mechanisms underlying DFU are comprise a triad: Neuropathy,vascular insufficiency, and secondary infection due to trauma of the foot.Standard local and invasive care along with novel approaches like stem celltherapy pave the way to reduce morbidity, decrease amputations, and preventmortality from DFU. In this manuscript, we review the current literature withfocus on the pathophysiology, preventive options, and definitive management ofDFU.

关 键 词：Diabetes ULCER FOOT ANTIBIOTICS REVASCULARIZATION Cell therapy 

分 类 号：R587.2[医药卫生—内分泌]