COVID-19 related liver injuries in pregnancy  

作　　者：Metodija Sekulovski Simona Bogdanova-Petrova Monika Peshevska-Sekulovska Tsvetelina Velikova Tsvetoslav Georgiev 

机构地区：[1]Department of Anesthesiology and Intensive Care,University Hospital Lozenetz,Sofia 1407,Bulgaria [2]Medical Faculty,Sofia University St.Kliment Ohridski,Sofia 1407,Bulgaria [3]First Department of Internal Medicine,Medical University-Varna,Varna 9010,Bulgaria [4]Clinic of Rheumatology,University Hospital“St.Marina”,Varna 9010,Bulgaria [5]Department of Gastroenterology,University Hospital Lozenetz,Sofia 1407,Bulgaria [6]Department of Clinical Immunology,University Hospital Lozenetz,Sofia 1407,Bulgaria

出　　处：《World Journal of Clinical Cases》2023年第9期1918-1929,共12页世界临床病例杂志

摘　　要：While severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)quickly spread across the globe,our understanding of its pathogenic mechanisms evolved.Importantly,coronavirus disease 2019(COVID-19)is now considered a syndromic multisystem inflammatory disease involving not only the respiratory system but also the cardiovascular,excretory,nervous,musculoskeletal,and gastrointestinal systems.Moreover,a membrane-bound form of angiotensin-converting enzyme 2,the entry receptor for SARS-CoV-2,is expressed on the surface of cholangiocytes and hepatocytes,suggesting the potential of COVID-19 to involve the liver.With the widespread distribution of SARS-CoV-2 throughout the population,infection during pregnancy is no longer a rare occurrence;however,little is known about the course of hepatic injuries and related outcomes in pregnant SARS-CoV-2-positive women.Thus,the understudied topic of COVID-related liver disease during pregnancy poses a great challenge for the consulting gynecologist and hepatologist.In this review,we aim to describe and summarize potential liver injuries in pregnant women with COVID-19.

关 键 词：COVID-19 Liver injury PREGNANCY SARS-CoV-2 Angiotensin-converting enzyme 2 receptors 

分 类 号：R714.251[医药卫生—妇产科学]