Hepatobiliary system and intestinal injury in new coronavirus infection(COVID-19):A retrospective study  

作　　者：Konstantin V Kozlov Konstantin V Zhdanov Anna K Ratnikova Vyacheslav A Ratnikov Artem V Tishkov Vladimir Grinevich Yuriy A Kravchuk Panteley I Miklush Polina O Nikiforova Vera V Gordienko Alexander F Popov Boris G Andryukov 

机构地区：[1]Department of Infectious Disease,Military Medical Academy Named After SM.Kirov,Saint-Petersburg 194044,Russia [2]Department of Admission,Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency",Saint-Petersburg 194291,Russia [3]Department of Roentgenology,Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency",Saint-Petersburg 194291,Russia [4]Department of Physics,Mathematics and Informatics,FSBEI HE IP.Pavlov SPbSMU MOH Russia,Saint-Petersburg 197022,Russia [5]2nd Department of Therapy(Advanced Medical Education),Military Medical Academy Named After SM.Kirov,Saint-Petersburg 194044,Russia [6]School of Medicine,Far Eastern Federal University,Vladivostok 690922,Russia

出　　处：《World Journal of Clinical Cases》2023年第10期2226-2236,共11页世界临床病例杂志

基　　金：study was reviewed and approved by the independent ethics committee of the Military Medical Academy named after SM.Kirov,protocol(Approval No.246).

摘　　要：BACKGROUND An important area of effective control of the coronavirus disease 19(COVID-19)pandemic is the study of the pathogenic features of severe acute respiratory syndrome coronavirus 2 infection,including those based on assessing the state of the intestinal microbiota and permeability.AIM To study the clinical features of the new COVID-19 in patients with mild and moderate severity at the stage of hospitalization,to determine the role of hepatobiliary injury,intestinal permeability disorders,and changes in the qualitative and quantitative composition of the microbiota in the development of systemic inflammation in patients with COVID-19.METHODS The study was performed in 80 patients with COVID-19,with an average age of 45 years,19 of whom had mild disease,and 61 had moderate disease severity.The scope of the examination included traditional clinical,laboratory,biochemical,instrumental,and radiation studies,as well as original methods for studying microbiota and intestinal permeability.RESULTS The clinical course of COVID-19 was studied,and the clinical and biochemical features,manifestations of systemic inflammation,and intestinal microbiome changes in patients with mild and moderate severity were identified.Intestinal permeability characteristics against the background of COVID-19 were evaluated by measuring levels of proinflammatory cytokines,insulin,faecal calprotectin,and zonulin.CONCLUSION This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COVID-19 severity.

关 键 词：Novel coronavirus infection COVID-19 SARS-CoV-2 ZONULIN Faecal calprotectin MICROBIOTA 

分 类 号：R511[医药卫生—内科学]