Optimal laboratory testing protocol for patients with acne taking oral isotretinoin  

作　　者：Yu Jeong Park Hui Young Shin Woo Kyoung Choi Ai-Young Lee Seung Ho Lee Jong Soo Hong 

机构地区：[1]Department of Dermatology,Dongguk University Ilsan Hospital,College of Medicine,Dongguk University,Goyang 10326,South Korea

出　　处：《World Journal of Clinical Cases》2023年第11期2435-2442,共8页世界临床病例杂志

基　　金：Supported by the Dongguk University Research Program(2021).

摘　　要：BACKGROUND Isotretinoin is a widely prescribed drug for various dermatological conditions,especially acne.Blood tests are routinely performed to monitor its side effects.However,the optimal testing schedule remains controversial.AIM To evaluate the laboratory monitoring tests and schedules of patients with acne taking isotretinoin to determine the most efficient testing regimen.METHODS We retrospectively reviewed electronic medical records from the Dermatology Department of Dongguk University Ilsan Hospital from 2005 to 2020 for patients prescribed isotretinoin for acne who underwent monthly blood tests.RESULTS Aspartate aminotransferase(AST),alanine aminotransferase(ALT),and trigly-ceride(TG)levels significantly changed between 5 and 6 mo when the total prescription period and dose variables were considered altogether.The high-density lipoprotein level also significantly changed between 5 and 6 mo.However,low-density lipoprotein(LDL)and total cholesterol levels significantly changed between 1 and 2 mo.CONCLUSION We recommend testing AST,ALT,and TG levels once every 5 to 6 mo.We also suggest testing LDL and total cholesterol levels during the first and second months.

关 键 词：Acne vulgaris ISOTRETINOIN Clinical laboratory techniques Vitamin A LIVER 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]