COVID-19 related biliary injury:A review of recent literature  

作　　者：Sujani Yadlapati Simone A.Jarrett Daniel Baik Adib Chaaya 

机构地区：[1]Department of Gastroenterology,Cooper University Hospital,Cooper Medical School of Rowan University,Camden,NJ 08103,United States [2]Department of Internal Medicine,Einstein Medical Center,Sidney Kimmel Medical College,Thomas Jefferson University,Philadelphia,PA 19140,United States

出　　处：《World Journal of Gastroenterology》2023年第14期2127-2133,共7页世界胃肠病学杂志（英文版）

摘　　要：Since its emergence in 2019,it has become apparent that coronavirus 2019(COVID-19)infection can result in multi systemic involvement.In addition to pulmonary symptoms,hepatobiliary involvement has been widely reported.Extent of hepatic involvement ranges from minor elevation in liver function tests(LFTs)to significant hepatocellular or cholestatic injury.In majority of cases,resolution of hepatic injury or improvement in LFTs is noted as patients recover from COVID-19 infection.However,severe biliary tract injury progressing to liver failure has been reported in patients requiring prolonged intensive care unit stay or mechanical ventilation.Due to the timing of its presentation,this form of progressive cholestatic injury has been referred to as COVID-19 cholangiopathy or post-COVID-19 cholangiopathy,and can result in devastating consequences for patients.COVID-19 cholangiopathy is recognized by dramatic elevation in serum alkaline phosphatase and bilirubin and radiologic evidence of bile duct injury.Cholangiopathy in COVID-19 occurs weeks to months after the initial infection and during the recovery phase.Imaging findings and pathology often resemble bile duct injury associated with primary or secondary sclerosing cholangitis.Etiology of COVID-19 cholangiopathy is unclear.Several mechanisms have been proposed,including direct cholangiocyte injury,vascular compromise,and cytokine release syndromes.This review summarizes existing data on COVID-19 cholangiopathy,including reported cases in the literature,proposed pathophysiology,diagnostic testing,and long-term implications.

关 键 词：COVID-19 cholangiopathy Post COVID-19 cholangiopathy Cholestatic injury Liver transplant 

分 类 号：R511[医药卫生—内科学] R575.7[医药卫生—临床医学]