Anti-inflammatory effect and antihepatoma mechanism of carrimycin  

作　　者：Xiu-Yan Li Yu-Ting Luo Yan-Hong Wang Zhi-Xin Yang Yu-Zhou Shang Qing-Xia Guan 

机构地区：[1]Key Laboratory of Basic and Application Research of Beiyao,Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang Province,China

出　　处：《World Journal of Gastroenterology》2023年第14期2134-2152,共19页世界胃肠病学杂志（英文版）

基　　金：Supported by Heilongjiang Natural Science Foundation,No.LH2022H085 and H2016057;Scientific Research Project of Heilongjiang Health Committee,No.2020-293.

摘　　要：BACKGROUND New drugs are urgently needed for the treatment of liver cancer, a feat that could be feasibly accomplished by finding new therapeutic purposes for marketed drugs to save time and costs. As a new class of national anti-infective drugs, carrimycin(CAM) has strong activity against gram-positive bacteria and no cross resistance with similar drugs. Studies have shown that the components of CAM have anticancer effects.AIM To obtain a deeper understanding of CAM, its distribution, metabolism and antiinflammatory effects were assessed in the organs of mice, and its mechanism of action against liver cancer was predicted by a network pharmacology method.METHODS In this paper, the content of isovaleryl spiramycin Ⅲ was used as an index to assess the distribution and metabolism of CAM and its effect on inflammatory factors in various mouse tissues and organs. Reverse molecular docking technology was utilized to determine the target of CAM, identify each target protein based on disease type, and establish a target protein-disease type network to ascertain the effect of CAM in liver cancer. Then, the key action targets of CAM in liver cancer were screened by a network pharmacology method, and the core targets were verified by molecular docking and visual analyses.RESULTS The maximum CAM concentration was reached in the liver, kidney, lung and spleen 2.5 h after intragastric administration. In the intestine, the maximum drug concentration was reached 0.5 h after administration. In addition, CAM significantly reduced the interleukin-4(IL-4) levels in the lung and kidney and especially the liver and spleen;moreover, CAM significantly reduced the IL-1β levels in the spleen, liver, and kidney and particularly the small intestine and lung. CAM is predicted to regulate related pathways by acting on many targets,such as albumin, estrogen receptor 1, epidermal growth factor receptor and caspase 3, to treat cancer, inflammation and other diseases.CONCLUSION We determined that CAM inhibited inflammation. We also predicted

关 键 词：Carrimycin Reverse molecular docking Network pharmacology Liver cancer ANTIINFLAMMATORY Anti-hepatoma 

分 类 号：R965[医药卫生—药理学]