基于STM32的生物电阻抗测量系统的设计与应用  

Design and Application of a Bioelectrical Impedance Measurement System Based on STM32

作　　者：李曙 王直[1] 滕凯 李想 LI Shu;WANG Zhi;TENG Kai;LI Xiang(School of Electronic Information,Jiangsu University of Science and Technology,Zhenjiang Jiangsu 212000,China;Department of Blood Transfusion,Zhenjiang Fourth People’s Hospital,Zhenjiang Jiangsu 212000,China;School of Computer Science,Jiangsu University of Science and Technology,Zhenjiang Jiangsu 212000,China)

机构地区：[1]江苏科技大学电子信息学院,江苏镇江212000 [2]镇江第四人民医院输血科,江苏镇江212000 [3]江苏科技大学计算机学院,江苏镇江212000

出　　处：《电子器件》2023年第1期268-274,共7页Chinese Journal of Electron Devices

基　　金：国家自然科学基金项目(51875270)。

摘　　要：为了更好地了解患者的血凝病理状况,方便医生及时用药,基于STM32和AD5933设计了一种血凝电阻抗测量系统。使用该系统测量标准电阻、电容构成的RC并联网络,与TH2832LCR电桥仪对比,误差小于0.9%;进行标准电阻的扫频测量,误差小于0.5%。提出一种凝血因子反应时间R检测方法,对40组血样进行测量,并与实际R值对比,误差均小于4%;使用等浓度差的CaCl_(2)溶液与多组枸橼酸钠抗凝血混合,发现随着CaCl_(2)溶液浓度以0.025mol/L微量减小,R明显增大,符合生物学规律;在不同条件下对多组血样进行测量,误差均小于5%。结果表明该电阻抗测量系统可以用于凝血因子反应时间的检测,且具有较高的精度、灵敏度和较好的重复性、重现性。In order to better understand the blood coagulation pathological status of patients,facilifating doctors to timely adjust medica-tion,a bioelectrical impedance measurement system based on STM32 and AD5933 is designed.This system is used to measure the RC parallel network composed of standard resistance and capacitance,compared with TH2832 LCR bridge meter,the error is less than 0.9%.The sweep frequency measurement of the standard resistance is performed,and the error is less than 0.5%.A method for detec-ting blood coagulation factor reaction time of R is proposed,and 40 groups of blood samples are measured.Compared with the actual R value,the error is less than 4%.CaCl_(2) solutions of equal concentration difference are mixed with multiple groups of sodium citrate anti-coagulate blood,it is found that as the concentration of CaCl_(2) solution decreases slightly by 0.025 mol/L,R increases significantly,which conforms to the laws of biology.Multiple groups of blood samples are measured under different conditions,the error is less than 5%.The results indicate that the electrical impedance measurement system can be used for the detection of coagulation factor reaction time with high accuracy and sensitivity and good repeatability and reproducibility.

关 键 词：AD5933 电阻抗测量 凝血因子反应时间 枸橼酸钠抗凝血 

分 类 号：TP216[自动化与计算机技术—检测技术与自动化装置]