环二鸟苷酸调控铜绿假单胞菌生物被膜研究进展  

Research progress of cyclic diguanylate on the regulation of Pseudomonas aeruginosa biofilm

作　　者：费冰 刘莹[1] 任彦颖 郭梦雨 刘心伟[1] 刘冬梅[1] 李永伟[1] FEI Bing;LIU Ying;REN Yanying;GUO Mengyu;LIU Xinwei;LIU Dongmei;LI Yongwei(The Second Clinical Medical College of Henan University of Traditional Chinese Medicine,Key Laboratory of Pathogenic Microorganisms of Zhengzhou,Zhengzhou 450002,Henan,China)

机构地区：[1]河南中医药大学第二临床医学院郑州市病原微生物重点实验室,河南郑州450002

出　　处：《检验医学》2023年第2期186-189,共4页Laboratory Medicine

基　　金：河南省自然科学基金面上项目(202300410263);河南中医药大学研究生科研创新类项目(2021KYCX028)。

摘　　要：从浮游到生物被膜(BF)生命周期的转变能够促进细菌对非生物表面的黏附,逃避宿主免疫系统,增强其对常见抗菌药物的抗性,在导致人类病原菌感染率不断增加的同时,也大大增加了临床治疗的难度。第二信使环二鸟苷酸(c-di-GMP)对BF的调控起重要作用。通过直接靶向c-di-GMP信号传导抑制抗菌药物抗性和BF形成意义重大。文章对c-di-GMP在铜绿假单胞菌BF调控中的作用进行综述。The transition of bacteria from planktonic growth to biofilm(BF)life cycle can promote the adhesion of bacteria to non-biological surfaces,evade host immune system,and increase resistance to common antibiotics.The current BF-forming bacteria have an increasing probability of human infection and greatly increase the energy and time required for treatment and recovery.The second messenger cyclic diguanylate(c-di-GMP)plays a role in the regulation of BF.The research on the treatment of antibiotic-resistant and BF-forming bacteria by directly targeting c-di-GMP signaling has shown promise.Therefore,this review summarizes the effect of c-di-GMP on the regulation of Pseudomonas aeruginosa BF.

关 键 词：环二鸟苷酸 铜绿假单胞菌 生物被膜 调控作用 

分 类 号：R446.1[医药卫生—诊断学]