不同NYHA分级射血分数降低心衰患者血浆CXCL16、sST2水平变化及其临床意义  

Changes and clinical significance of plasma CXCL16 and sST2 levels in patients with heart failure with different NYHA grades and reduced ejection fraction

作　　者：杨新利[1] 王丹[1] YANG Xinli;WANG Dan(Department of Cardiov ascular Medicine,First Afiliated Hospital of Henan University of Science and Technology,Henan Luoyang 471000)

机构地区：[1]河南科技大学第一附属医院心血管内科,河南洛阳471000

出　　处：《医学检验与临床》2023年第2期31-34,共4页Medical Laboratory Science and Clinics

摘　　要：目的:探讨不同NYHA分级射血分数降低心衰(HFREF)患者血浆趋化因子CXC配体16(CXCL16)、可溶性肿瘤发生抑制蛋白-2(sST2)水平变化及临床意义。方法:选取我院2020年3月-2022年1月收治的132例HFREF患者为HFREF组[射血分数(LVEF)<50%],同期81例射血分数保留心衰(HFPEF)患者为HFPEF组(LVEF≥50%)。比较两组入院时血浆CXCL16、sST2水平,比较不同NYHA分级、LVEF的HFREF患者血浆CXCL16、sST2水平,分析血浆CXCL16、sST2水平与NYHA分级、LVEF的相关性,以及上述指标水平发生HFREF的危险度。结果:入院时,HFREF组血浆CXCL16、sST2水平较HFPEF组高(P<0.05);不同NYHA分级的HFREF患者血浆CXCL16、sST2水平比较,Ⅱ级<Ⅲ级<Ⅳ级,差异具有统计学意义(P<0.05);LVEF<30%的HFREF患者的血浆CXCL16、sST2水平高于30%~40%的HFREF患者、高于41%~50%的HFREF患者(P<0.05);相关性分析结果显示,入院时,HFREF患者血浆CXCL16、sST2水平均与NYHA分级呈正相关,而血浆CXCL16、sST2水平均与LVEF呈负相关(P<0.05);危险度分析发现,入院时血浆CXCL16、sST2高水平患者发生HFREF的危险度分别是低水平的3.093、4.086倍(P<0.05)。结论:血浆CXCL16、sST2水平与心功能紧密相关,检测其水平能为临床诊断HFREF提供依据。Objective:To investigate the changes and clinical significance of plasma chemokine CXC ligand 16(CXCL16)and soluble tumor suppressor protein-2(sST2)levels in patients with heart failure(HFREF)with different NYHA grades and reduced ejection fraction.Methods:132 HFREF patients admitted to our hospital from March 2020 to January 2022 were selected as HFREF Group[ejection fraction(LVEF)<50%],and 81 HFPEF patients in the same period were selected as HFPEF group(LVEF≥50%).The plasma CXCL16 and sST2 levels of the two groups at admission were compared.The plasma CXCL16 and sST2 levels of HFREF patients with different NYHA grades and LVEF were compared.The correlation between the plasma CXCL16 and sST2 levels and NYHA grades and LVEF was analyzed,as well as the impact of each index on the risk of HFREF.Results:The levels of CXCL16 and sST2 in HFREF group were higher than those in HFPEF group(P<0.05);The levels of CXCL16 and sST2 in the plasma of HFREF patients with different NYHA grades were significantly different(P<0.05);The plasma levels of CXCL16 and sST2 in HFREF patients with LVEF<30%were higher than those in HFREF patients with LVEF<30%,higher than those in HFREF patients with LVEF<30%and higher than those in HFREF patients with LVEF<41%and higher than those in HFREF patients with LVEF<30%(P<0.05);The results of correlation analysis showed that the plasma CXCL16 and sST2 levels of HFREF patients were positively correlated with NYHA grade at admission,while the plasma CXCL16 and sST2 levels were negatively correlated with LVEF(P<0.05);The risk analysis found that the risk of HFREF in patients with high levels of CXCL16 and sST2 was 3.093 and 4.086 times higher than that in patients with low levels(P<0.05).Conclusion:The plasma levels of CXCL16 and sST2 are closely related to cardiac function,and the detection of CXCL16 and sST2can provide evidence for clinical diagnosis of HFREF.

关 键 词：CXCL16 sST2 射血分数降低心衰 NYHA分级 

分 类 号：R541.6[医药卫生—心血管疾病]