冠状动脉内皮细胞线粒体损伤在心肌梗死中的研究进展  

Mitochondrial Injury of Coronary Endothelial Cells in Myocardial Infarction

作　　者：张国贤 彭瑜[2] 张钲[1,2] ZHANG Guoxian;PENG Yu;ZHANG Zheng(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China;The First Hospital of Lanzhou University,Gansu Key Laboratory of Cardiovascular Disease,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院甘肃省心血管疾病重点实验室,甘肃兰州730000

出　　处：《心血管病学进展》2023年第3期203-207,共5页Advances in Cardiovascular Diseases

基　　金：甘肃省心血管病临床医学研究中心基金(18JR2FA005);兰州大学第一医院院内基金(ldyyyn2020-49)。

摘　　要：心血管疾病严重影响人们健康。心血管疾病中的心肌梗死严重危及生命。研究表明,冠状动脉内皮细胞的损伤会加重心肌梗死,而内皮细胞线粒体在内皮细胞损伤中扮演了重要角色,因此内皮细胞线粒体的研究也越来越受到人们关注。现就冠状动脉内皮细胞线粒体的结构及其损伤在氧化应激、炎症、动脉粥样硬化和心肌梗死后缺血再灌注损伤方面的研究进展和治疗进行综述,以期为心肌梗死的相关研究及治疗提供参考。Cardiovascular disease seriously affects people’s health.Myocardial infarction in cardiovascular disease is seriously life-threatening.Studies have shown that damage to coronary endothelial cells can aggravate myocardial infarction,and endothelial cell mitochondria play an important role in endothelial cell damage,so the study of endothelial cell mitochondria has also attracted more and more attention.This article reviews the research progress and treatment of the mitochondrial structure of coronary endothelial cells and its quality control damage in oxidative stress,inflammation,atherosclerosis and ischemia reperfusion injury during myocardial infarction,in order to provide reference for the related research and treatment of myocardial infarction.

关 键 词：内皮细胞线粒体损伤 心肌梗死 氧化应激 线粒体质量控制 炎症反应 缺血再灌注损伤 

分 类 号：R542.22[医药卫生—心血管疾病]