雌性大鼠和雄性大鼠高尿酸血症动物模型的动态比较  

Dynamic Comparison of Hyperuricemia Animal Model in Male and Female Rats

作　　者：阿依努·艾力 布威阿依谢姆·努尔麦麦提 阿迪拉·阿扎提[1] 迪丽达尔·希力甫[2] Aynur·Aili;Buviayxem·Nurmamat;Adila·Azat;Dildar·Xerip(The First Clinical College of Xinjiang Medical University,Urumqi 830011,Xinjiang,China;Heart Center of The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang,China)

机构地区：[1]新疆医科大学第一临床学院,新疆乌鲁木齐830011 [2]新疆医科大学第一附属医院心脏中心,新疆乌鲁木齐830011

出　　处：《心血管病学进展》2023年第3期277-282,共6页Advances in Cardiovascular Diseases

基　　金：新疆维吾尔自治区域协同创新专项—上海合作组织科技伙伴计划及国际科技合作项目(22E01037)。

摘　　要：目的采用酵母膏联合氧嗪酸钾构建雌性大鼠和雄性大鼠高尿酸模型,观察持续高尿酸血症对雌性和雄性大鼠血清生化指标及心脏、肾脏、尾动脉和主动脉的病理改变的影响。方法以酵母膏21 g/(kg·d)给予喂养,氧嗪酸钾以200 mg/(kg·d)持续腹腔注射28 d建立高尿酸血症雌性和雄性大鼠模型。结果酵母膏21 g/(kg·d)喂养联合氧嗪酸钾200 mg/(kg·d)持续腹腔注射28 d,雌性大鼠血清尿酸水平可维持在更高水平,高血清尿酸水平使大鼠心脏、肾脏和动脉也发生了一系列病理改变,且雌性大鼠病理改变较雄性大鼠明显。结论雌性大鼠的造模效果优于雄性大鼠,应为建立高尿酸血症动物模型的首要选择。Objective Using yeast extract combined with oxonic acid potassium to construct hyperuric acid model of female and male rats,to observe the effect of persistent hyperuricemia on serum indexes and pathological changes of heart,kidney,tail artery and aorta in female and male rats.Methods Feeding yeast extract 21 g/(kg·d),and oxonic acid potassium was continuously injected intraperitoneally for 28 days at 200 mg/(kg·d)to establish the female and male models of hyperuricemia.Results Yeast extract 21 g/(kg·d)feeding combined with oxonic acid potassium 200 mg/(kg·d)continuous intraperitoneal injection for 28 days,the serum uric acid level of female rats can maintain at a higher level,and the high serum uric acid level also causes a series of pathological changes in the heart,kidney and arteries of rats,and the pathological changes of female rats are more obvious than that of male rats.Conclusion The modeling effect of female rats is better than that of male rats,which should be the first choice to establish the animal model of hyperuricemia.

关 键 词：高尿酸血症 动物模型 酵母膏 氧嗪酸钾 雄性大鼠 

分 类 号：R589.7[医药卫生—内分泌] R-332[医药卫生—内科学]