甘肃地区健康人群甲状旁腺素水平分析及参考区间的建立  

Parathyroid hormone level in healthy people in Gansu and establishment of reference interval

作　　者：荆晓 梅澍[1] 牛继国[1] 阎沛佩 田彩平[2] 曾贤伍[1] JING Xiao;MEI Shu;NIU Jiguo;YAN Peipei;TIAN Caiping;ZENG Xianwu(Department of Nuclear Medicine,Gansu ProvincialCancer Hospital,Lanzhou,Gansu 730050,China;Medical Molecular Biology Research Center,Gansu Provincial Academic Institute for Medical Research,Lanzhou,Gansu 730050,China)

机构地区：[1]甘肃省肿瘤医院核医学科,甘肃兰州730050 [2]甘肃省医学科学研究院医学分子生物学研究中心,甘肃兰州730050

出　　处：《国际检验医学杂志》2023年第7期798-802,807,共6页International Journal of Laboratory Medicine

基　　金：甘肃省自然科学基金项目(20JR5RA158);甘肃省卫生行业科研计划项目(GSWSKY-2019-35);兰州市科技发展指导性计划项目(2022-ZD-81);兰州市科技计划项目(2021-1-92)。

摘　　要：目的分析甘肃地区健康人群血清甲状旁腺素(PTH)水平,探讨甘肃地区不同性别、不同年龄人群PTH水平的差异,建立甘肃地区健康人群的PTH参考区间。方法选取甘肃地区表观健康人群752例,采集分离血清,检测血清中PTH水平,同时检测血清25羟维生素D[25(OH)D]水平。结果甘肃地区健康人群的PTH水平为54.21(38.86,74.85)pg/mL,采用百分位数法(P_(2.5)~P_(97.5))确定参考区间为22.23~118.74 pg/mL。健康女性血清PTH水平高于男性(P<0.05);在20~29岁年龄段中,女性PTH水平明显高于男性(P<0.05);不同年龄段分组比较结果显示,血清PTH水平差异无统计学意义(P>0.05)。甘肃省健康人25(OH)D水平为15.81(13.63,18.89)ng/mL,25(OH)D水平随着年龄的增长而升高,女性25(OH)D水平明显低于男性(P<0.05)。维生素D严重缺乏、缺乏、不足率分别为15.3%、68.1%、12.9%。血清PTH与25(OH)D呈负相关(r=-0.200,P<0.05),即血清PTH水平随着25(OH)D水平增高而降低。结论该研究建立了甘肃地区健康人群血清PTH的参考区间,以期为临床诊疗提供详实准确的参考依据。各医疗机构实验室应当建立适用于各自实验室的参考范围。Objective To analyze the serum parathyroid hormone(PTH)level of healthy people in Gansu,explore the differences of PTH levels among people of different sexes and ages in Gansu,and establish the reference interval of PTH in healthy people in Gansu.Methods A total of 752 healthy subjects who underwent physical examination were recollected in Gansu,the levels of PTH and 25 hydroxyvitamin D[25(OH)D]in serum were detected.Results The PTH level of healthy people in Gansu was 54.21(38.86,74.85)pg/mL,and the reference range was 22.23-118.74 pg/mL determined by percentile method(P_(2.5)~P_(97.5)).The serum PTH level of women was higher than that of men(P<0.05),in the age range of 20-29 years,the PTH level of women was significantly higher than that of men(P<0.05).The results of different age groups showed that there was no significant difference in serum PTH levels(P>0.05).The 25(OH)D level of healthy people in Gansu was 15.81(13.63,18.89)ng/mL,the level of 25(OH)D increased with age,and the level of 25(OH)D of women was significantly lower than that of men(P<0.05).The rates of severe deficiency,deficiency,and insufficiency were 15.3%,68.1%,12.9%respectively.Serum PTH was negatively correlated with 25(OH)D(r=-0.200,P<0.05),and serum PTH level decreased with the increase of 25(OH)D level.Conclusion This study establishes the reference interval of serum PTH of healthy people in Gansu,and provides detailed and accurate reference for clinical diagnosis and treatment.Medical laboratories should establish reference ranges for their respective laboratories.

关 键 词：甲状旁腺素 参考区间 维生素D 甘肃地区 

分 类 号：R446.1[医药卫生—诊断学]