自噬核心蛋白Beclin 1在动物生殖生理中的作用研究进展  

Research Progress on the Role of Autophagy Core Protein Beclin 1 in Reproductive Physiology

作　　者：柯璐 吴英杰[1] 秦应和[1] KE Lu;WU Yingjie;QING Yinghe(College of Animal Science and Technology,China Agricultural University,Beijing 100193,China)

机构地区：[1]中国农业大学动物科学技术学院,北京100193

出　　处：《中国畜牧杂志》2023年第4期39-44,共6页Chinese Journal of Animal Science

基　　金：财政部和农业农村部:国家现代农业产业技术体系资助(CARS-43);和田地区特色畜禽安全高效生产关键技术集成与示范(2020B01004)。

摘　　要：自噬是一种进化上高度保守的自我消化过程,是维持细胞内稳态所必需的。Beclin 1(Becn1)是酵母自噬相关基因6(ATG6)的同源物,Beclin 1蛋白在自噬中起核心作用,与多种因子相互作用,介导自噬蛋白定位于自噬前体结构而推进自噬进程。Beclin 1的功能障碍会导致动物生育力下降等多种疾病,且Beclin 1与生殖系统肿瘤发生也存在多种联系。本文综述了Beclin 1在动物生殖生理以及生殖系统恶性疾病中的研究进展,讨论了Beclin 1对于维持生殖系统健康的重要性,为提高动物繁殖力及治疗人类繁殖障碍提供参考。Autophagy is an evolutionarily highly conserved self-digestion process that is necessary to maintain cellular homeostasis.Beclin 1(Becn1)is the ortholog of yeast autophagy related gene 6(ATG6).Beclin 1 plays a central role in autophagy and interacts with a variety of factors,mediating autophagy protein localization to pre-autophagosomal structure and promoting autophagy process.Depletion of Beclin 1 can lead to a variety of diseases including decreased fertility,and studies have found that Beclin 1 is also associated with the occurrence of reproductive system tumors.This paper reviews the research progress on the role of Beclin 1 in reproductive physiology and malignant diseases of reproductive system,discusses the importance of Beclin 1 in maintaining the health of reproductive system,and provides some references for the treatment of human reproductive disorders and improvement of animal fertility.

关 键 词：Beclin 1 自噬 睾丸 卵巢 癌症 

分 类 号：S814.1[农业科学—畜牧学]