银杏叶片联合替格瑞洛治疗冠心病心绞痛临床研究  

Clinical Study on Yinxingye Tablets Combined with Ticagrelor for Angina Pectoris of Coronary Heart Disease

作　　者：张南南 张利霞 秦英华 ZHANG Nannan;ZHANG Lixia;QIN Yinghua

机构地区：[1]鹤壁市人民医院心血管内科,河南鹤壁458030

出　　处：《新中医》2023年第5期76-80,共5页New Chinese Medicine

摘　　要：目的:观察银杏叶片联合替格瑞洛治疗冠心病心绞痛的临床疗效及对心功能、血液流变学的影响。方法:将90例冠心病心绞痛患者采用随机数字表法分为对照组和观察组各45例。对照组给予替格瑞洛片治疗,观察组在对照组基础上加用银杏叶片治疗,2组均连续治疗2个月。比较2组临床疗效及不良反应,并比较2组治疗前后中医证候积分、心绞痛发作情况、心功能及血液流变学指标。结果:治疗后,2组各中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。观察组治疗总有效率93.33%,高于对照组82.22%(P<0.05)。治疗后,2组心绞痛发作次数及发作持续时间均减少(P<0.05),且观察组少于对照组(P<0.05)。治疗后,2组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)降低(P<0.05),左室射血分数(LVEF)升高(P<0.05),且观察组LVESD、LVEDD低于对照组(P<0.05),LVEF高于对照组(P<0.05)。治疗后,2组全血比黏度、血浆比黏度、全血还原黏度、纤维蛋白原(FIB)均降低(P<0.05),且观察组低于对照组(P<0.05)。观察组不良反应发生率4.44%,低于对照组15.55%(P<0.05)。结论:银杏叶片联合替格瑞洛治疗冠心病心绞痛可提高临床疗效,减少不良反应,减少心绞痛发作次数和持续时间,改善心功能及血液流变学。Objective:To observe the clinical effect of Yinxingye Tablets combined with Ticagrelor on angina pectoris of coronary heart disease and its effects on the heart function and hemorheology. Methods:A total of 90 patients with angina pectoris of coronary heart disease were divided into the control group and the observation group according to the random number table method,with 45 cases in each group. The control group was given Ticagrelor, and the observation group was additionally treated with Yinxinye Tablets based on the treatment of the control group. The two groups were treated for 2 months. The clinical effects, adverse reactions, traditional Chinese medicine(TCM) syndrome scores, incidence of angina pectoris, heart function and hemorheology indexes in the two groups were compared. Results: After treatment, the TCM syndrome scores in the two groups were decreased(P<0.05), and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05). The total effective rate was 93.33% in the observation group,higher than that of 82.22% in the control group(P<0.05). After treatment,the frequency and duration of angina pectoris attacks in both groups were reduced(P<0.05),and the frequency and duration of angina pectoris attacks in the observation group were lower than those in the control group(P<0.05). After treatment, the left ventricular end-systolic diameter(LVESD) and left ventricular end-diastolic diameter(LVEDD) in both groups were decreased(P<0.05) and the left ventricular ejection fraction(LVEF) was increased(P<0.05), and the LVESD and LVEDD in the observation group were lower than those in the control group(P<0.05),and the LVEF was higher than that in the control group(P<0.05). After treatment, the whole blood contrast viscosity, plasma specific viscosity,blood reduced viscosity and plasma fibrinogen(FIB) in both groups were decreased(P<0.05),and the above four hemorheology indexes in the observation group were lower than those in the control group(P<0.05). The incidence of adver

关 键 词：冠心病心绞痛 银杏叶片 替格瑞洛 心功能 血液流变学 

分 类 号：R541.4[医药卫生—心血管疾病]