黄柏水煎液联合封闭式负压引流技术冲洗治疗下肢静脉性溃疡临床疗效  

Clinical Effect of Phellodendri Chinensis Cortex Decoction Combined with Irrigation by Vacuum Sealing Drainage for Venous Leg Ulcers

作　　者：陈琼 叶海东[1] 凌财才 CHEN Qiong;YE Haidong;LING Caicai

机构地区：[1]温州市中医院中医外科,浙江温州325029

出　　处：《新中医》2023年第5期122-125,共4页New Chinese Medicine

基　　金：温州市基础性科研项目(Y2020857)。

摘　　要：目的:观察黄柏水煎液联合封闭式负压引流技术(VSD)冲洗治疗下肢静脉性溃疡(VLU)的临床疗效。方法:采用随机数字表法将80例VLU患者分为试验组与对照组各40例。对照组给予0.9%氯化钠溶液联合VSD冲洗治疗,试验组给予黄柏水煎液联合VSD冲洗治疗。比较2组治疗前后中医证候积分、创面面积、超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC)水平;比较2组引流管堵塞情况、创面愈合率、创面细菌培养转阴率、临床疗效、住院天数、住院总费用及不良反应发生情况。结果:试验组总有效率95.00%,高于对照组72.50%(P<0.05)。治疗后,2组中医证候积分、创面面积、hs-CRP、WBC水平均较治疗前降低(P<0.05),且试验组低于对照组(P<0.05)。试验组创面愈合率、创面细菌培养转阴率高于对照组(P<0.05),住院时间、住院总费用少于对照组(P<0.05)。2组引流管堵塞率比较,差异无统计学意义(P>0.05),且2组均未发生严重不良反应。结论:黄柏水煎液联合VSD冲洗治疗VLU疗效确切,可提高患者创面愈合率,降低炎性反应,缩短住院时间,安全性较高。Objective: To observe the clinical effect of Phellodendri Chinensis Cortex Decoction combined with irrigation by vacuum sealing drainage(VSD) for venous leg ulcers(VLU). Methods:A total of80 cases of VLU patients were divided into the trial group and the control group according to the random number table method, with 40 cases in each group. The control group was treated with 0.9% sodium chloride solution combined with VSD irrigation,and the trial group was treated with Phellodendri Chinensis Cortex Decoction combined with VSD irrigation. Traditional Chinese medicine(TCM) syndrome scores,wound area and levels of hypersensitive C-reactive protein(hs-CRP) and white blood cell counts(WBC)before and after treatment were compared between the two groups;drainage tube blockage, wound healing rate,negative conversion rate of wound bacterial culture,clinical effects,length of hospital stay,total hospitalization expenses and incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 95.00% in the trial group,higher than that of 72.50% in the control group(P<0.05). After treatment,TCM syndrome scores,wound area and levels of hs-CRP and WBC in the two groups were decreased when compared with those before treatment(P<0.05), and the above indexes in the trial group were lower than those in the control group(P<0.05). The wound healing rate and the negative conversion rate of wound bacterial culture in the trial group were higher than those in the control group(P<0.05),and the length of hospital stay and the total hospitalization expenses in the trial group were shorter and lower than those in the control group(P<0.05). There was no significant difference being found in the comparison of the drainage tube blockage rates between the two groups(P>0.05),and no serious adverse reaction occurred in the two groups. Conclusion: Phellodendri Chinensis Cortex Decoction combined with VSD irrigation for VLU has a definite curative effect,and can improve the wound healing rate,reduce inflammatory

关 键 词：下肢静脉性溃疡 黄柏水煎液 封闭式负压引流技术 超敏C-反应蛋白 白细胞计数 

分 类 号：R543.6[医药卫生—心血管疾病]