疏肝理气活血化瘀方治疗气滞血瘀型子宫内膜异位症临床研究  

Clinical Study on Shugan Liqi Huoxue Prescription for Endometriosis of Qi Stagnation and Blood Stasis Type

作　　者：张蓉蓉[1] 吴罗金 ZHANG Rongrong;WU Luojin

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]台州市中医院中医治未病科,浙江台州318000

出　　处：《新中医》2023年第5期136-140,共5页New Chinese Medicine

摘　　要：目的:观察疏肝理气活血化瘀方在气滞血瘀型子宫内膜异位症患者中的治疗效果。方法:选取106例子宫内膜异位症患者为研究对象,采用信封法随机分为观察组与对照组各53例。对照组给予常规西药治疗,观察组在对照组基础上给予疏肝理气活血化瘀方治疗。比较2组临床疗效,比较2组治疗前后中医症状评分及性激素、血管生成因子、炎症因子水平。结果:观察组治疗总有效率96.23%,高于对照组84.91%(P<0.05)。治疗前,2组经期腹痛、经血夹块、腰膝酸软、性交痛、骶韧带触痛结节等中医症状评分比较,差异无统计学意义(P>0.05);治疗后,2组上述中医症状评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组血清黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)水平比较,差异无统计学意义(P>0.05);治疗后,2组LH、FSH、E2水平均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组血清肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)水平比较,差异无统计学意义(P>0.05);治疗后,2组血清TNF-α、IL-6、IL-8水平均降低,且观察组低于对照组(P<0.05)。治疗前,2组血清糖类抗原125 (CA125)、血管生成素-2 (Ang-2)、血管内皮生长因子(VEGF)水平比较,差异无统计学意义(P>0.05);治疗后,2组血清CA125、Ang-2、VEGF水平均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组血清基质金属蛋白酶-9 (MMP-9)、基质金属蛋白酶-2 (MMP-2)、单核细胞趋化蛋白-1(MCP-1)水平比较,差异无统计学意义(P>0.05);治疗后,2组血清MMP-9、MMP-2、MCP-1水平均降低(P<0.05),且观察组低于对照组(P<0.05)。结论:疏肝理气活血化瘀方在气滞血瘀型子宫内膜异位症患者中应用效果较佳,可显著改善患者临床症状及中医证候,有效调节性激素水平及血管生成因子水平,并减轻机体炎症反应。Objective: To observe the curative effect of Shugan Liqi Huoxue Prescription on patients with endometriosis of qi stagnation and blood stasis type. Methods: A total of 106 patients with endometriosis were selected as the research subjects and randomly divided into the observation group and the control group according to the sealed envelope method,with 53 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally given Shugan Liqi Huoxue Prescription based on the treatment of the control group. The clinical effects in both groups were compared. Before and after treatment,the traditional Chinese medicine(TCM) syndrome scores,and the levels of sex hormones, angiogenic factors and inflammatory factors in the two groups were also compared. Results: The total effective rate was 96.23% in the observation group, higher than that of84.91% in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparisons of TCM syndrome scores of abdominal pain during menstrual period, menstrual blood with stasis, sore and weak waist and knees, painful sexual intercourse and tender tubercle of sacral ligament between the two groups(P>0.05);after treatment,the above five TCM syndrome scores in both groups were decreased(P<0.05), and the above five scores in the observation group were lower than those in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparisons of levels of luteinizing hormone(LH),follicle stimulating hormone(FSH) and estradiol(E2)between the two groups(P>0.05);after treatment,the levels of LH,FSH and E2in the two groups were decreased(P<0.05), and the above three levels in the observation group were lower than those in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparisons of levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interleukin-8(IL-8)between the two groups(P>0.05);after treatmen

关 键 词：子宫内膜异位症 气滞血瘀证 疏肝理气活血化瘀方 中医症状评分 性激素 血管生成因子 炎症因子 

分 类 号：R271.9[医药卫生—中西医结合]