妊娠早期血清SerpinB1、NRG4水平对妊娠期糖尿病的预测价值  

Predictive value of serum SerpinB1 and NRG4 levels in early pregnancy for gestational diabetes mellitus

作　　者：史云 胡梦川 罗玲 崔晓荣 SHI Yun;HU Mengchuan;LUO Ling;CUI Xiaorong(Obstetrics Department,Southern University of Science and Technology Hospital,Shenzhen 518000,China)

机构地区：[1]南方科技大学医院产科,广东深圳518000

出　　处：《临床医学研究与实践》2023年第11期5-8,共4页Clinical Research and Practice

基　　金：深圳市南山区技术研发和创意设计项目(No.NS2021182)。

摘　　要：目的探讨妊娠早期血清丝氨酸蛋白酶抑制剂B1(SerpinB1)、神经调节蛋白4(NRG4)水平对妊娠期糖尿病(GDM)的预测价值。方法选取2020年12月至2022年2月在本院产检并分娩的161例GDM产妇作为GDM组,选取同期产检并分娩的152例非GDM产妇作为对照组。比较两组妊娠早期的血清SerpinB1、NRG4水平,分析其与其他血清学指标的相关性及对GDM发生和不良妊娠结局的影响及预测价值。结果GDM组的0、60、120 min口服葡萄糖耐量试验(OGTT)血糖、糖化血红蛋白(HbA1c)、甘油三酯(TG)及SerpinB1水平高于对照组,NRG4水平低于对照组(P<0.05)。妊娠早期血清SerpinB1水平与0、60、120 min OGTT血糖、HbA1c、TG呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关(P<0.05);妊娠早期血清NRG4水平与0、60、120 min OGTT血糖、HbA1c、低密度脂蛋白胆固醇(LDL-C)呈负相关,与HDL-C呈正相关(P<0.05)。Logistic回归分析结果显示,妊娠早期SerpinB1水平升高是GDM发生的危险因素(OR>1,P<0.05),NRG4水平升高是GDM发生的保护因素(OR<1,P<0.05)。受试者工作特征(ROC)曲线显示,血清SerpinB1、NRG4对GDM具有一定的预测价值。不良妊娠结局组的SerpinB1水平高于妊娠结局正常组,NRG4水平低于妊娠结局正常组(P<0.05)。Logistic回归分析结果显示,妊娠早期血清SerpinB1水平升高是GDM不良妊娠结局的危险因素(OR>1,P<0.05),NRG4水平升高是GDM不良妊娠结局的保护因素(OR<1,P<0.05)。ROC曲线显示,血清SerpinB1、NRG4对GDM不良妊娠结局具有一定的预测价值。结论妊娠早期血清SerpinB1、NRG4水平与GDM的发生及不良妊娠结局相关,在GDM发生及不良妊娠结局的预测中均有一定的临床价值。Objective To investigate the predictive value of serum serine proteinase inhibitor B1(SerpinB1)and neuregulin 4(NRG4)levels in early pregnancy for gestational diabetes mellitus(GDM).Methods A total of 161 GDM puerpera who underwent obstetric examination and delivery in our hospital from December 2020 to February 2022 were selected as GDM group,and 152 non-GDM puerpera who underwent obstetric examination and delivery in the same period were selected as control group.The serum SerpinB1 and NRG4 levels in early pregnancy of the two groups were compared,and their correlation with other serological indexes and their effects and predictive value on the occurrence of GDM and adverse pregnancy outcomes were analyzed.Results The levels of oral glucose tolerance test(OGTT)blood glucose at 0,60 and 120 min,glycated hemoglobin(HbA1c),triglyceride(TG)and SerpinB1 in the GDM group were higher than those in the control group,and the level of NRG4 was lower than that in the control group(P<0.05).The serum SerpinB1 level in early pregnancy was positively correlated with OGTT blood glucose at 0,60 and 120 min,HbA1c and TG,and negatively correlated with high density lipoprotein-cholesterol(HDL-C)(P<0.05).The serum NRG4 level in early pregnancy was negatively correlated with OGTT blood glucose at 0,60 and 120 min,HbA1c and low density lipoprotein-cholesterol(LDL-C),and positively correlated with HDL-C(P<0.05).Logistic regression analysis showed that elevated SerpinB1 level in early pregnancy was a risk factor for GDM(OR>1,P<0.05),elevated NRG4 level was a protective factor for GDM(OR<1,P<0.05).The receiver operating characteristic(ROC)curve showed that serum SerpinB1 and NRG4 had certain predictive value for GDM.The SerpinB1 level in the adverse pregnancy outcome group was higher than that in the normal pregnancy outcome group,and the NRG4 level was lower than that in the normal pregnancy outcome group(P<0.05).Logistic regression analysis showed that elevated serum SerpinB1 level in early pregnancy was a risk factor for adverse preg

关 键 词：妊娠期糖尿病 丝氨酸蛋白酶抑制剂B1 神经调节蛋白4 

分 类 号：R714.25[医药卫生—妇产科学]