甘草甜素片联合熊去氧胆酸治疗妊娠期胆汁淤积症的效果及对肝功能指标的影响  

Effect of glycyrrhizin tablets combined with ursodeoxycholic acid on intrahepatic cholestasis of pregnancy and its influences on liver function indexes

作　　者：贾莉 李小金 曹冬雪 JIA Li;LI Xiaojin;CAO Dongxue(the People's Hospital of Lintong District in Xi'an,Xi'an 710600;Xi'an Central Hospital,Xi'an 710003,China)

机构地区：[1]西安市临潼区人民医院,陕西西安710600 [2]西安市中心医院,陕西西安710003

出　　处：《临床医学研究与实践》2023年第11期62-64,共3页Clinical Research and Practice

摘　　要：目的探讨甘草甜素片联合熊去氧胆酸治疗妊娠期胆汁淤积症(ICP)的效果及对肝功能指标的影响。方法选取2018年1月至2020年12月本院收治的120例ICP患者为研究对象,按照患者入院编号的奇偶性将其分为对照组和观察组,各60例。对照组给予熊去氧胆酸片治疗,观察组在对照组基础上给予甘草甜素片治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的碱性磷酸酶(ALP)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、直接胆红素(DBiL)、总胆汁酸(TBA)水平均低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及白细胞介素-12(IL-12)水平均低于对照组,差异具有统计学意义(P<0.05)。观察组的不良妊娠结局总发生率低于对照组,差异具有统计学意义(P<0.05)。结论甘草甜素片联合熊去氧胆酸治疗ICP效果显著,可改善肝功能指标,减轻炎症反应,降低不良妊娠结局发生率,具有重要的临床应用价值。Objective To explore the effect of glycyrrhizin tablets combined with ursodeoxycholic acid on intrahepatic cholestasis of pregnancy(ICP)and its influences on liver function indexes.Methods A total of 120 patients with ICP admitted in our hospital from January 2018 to December 2020 were selected as the research objects and divided into control group and observation group according to the parity of admission number,with 60 cases in each group.The control group was treated with ursodeoxycholic acid tablets,and the observation group was treated with glycyrrhizin tablets on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of alkaline phosphatase(ALP),alanine aminotransferase(ALT),aspartate aminotransferase(AST),direct bilirubin(DBiL)and total bile acid(TBA)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of procalcitonin(PCT),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-12(IL-12)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Glycyrrhizin tablets combined with ursodeoxycholic acid in the treatment of ICP has a significant effect,it can improve liver function indexes,reduce inflammation reaction,and decrease the incidence of adverse pregnancy outcomes,which has important clinical application value.

关 键 词：妊娠期胆汁淤积症 甘草甜素片 熊去氧胆酸 肝功能指标 

分 类 号：R714.25[医药卫生—妇产科学]