儿童常年性过敏性鼻炎血清炎症因子水平与病情严重程度及鼻通气功能的关系  

The Relationship between Serum Inflammatory Factors and Severity Degree of Illness and Nasal Ventilation Function in Children with Perennial Allergic Rhinitis

作　　者：李慧[1] 聂雷[1] 张佩瑶 刘煜 高士培 LI Hui;NIE Lei;ZHANG Peiyao;LIU Yu;GAO Shipei(Baoding Children's Hospital,Baoding 071000,China;不详)

机构地区：[1]保定市儿童医院,河北保定071000

出　　处：《中外医学研究》2023年第8期69-73,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：保定市科技计划项目(2041ZF135)。

摘　　要：目的:探讨儿童常年性过敏性鼻炎(PAR)血清炎症因子水平与病情严重程度及鼻通气功能的关系。方法:连续性纳入2020年7月─2021年6月保定市儿童医院收治的100例PAR患儿作为PAR组,按照《儿童过敏性鼻炎诊疗-临床实践指南》将患儿分为轻度组(n=48)和中重度组(n=52),以同期的50例儿童健康体检者作为正常组。比较各组的血清炎症因子[超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)]水平,病情评估指标[过敏性鼻炎评分量表(SFAR)评分及症状视觉模拟量表(VAS)评分]及鼻通气功能指标[鼻气道阻力(NAR)、0~5 cm鼻腔容积(NCV0~5)、鼻腔最小横截面积(NMCA)、鼻呼吸量(NS)];采用Pearson相关系数分析血清炎症因子与病情评估指标、鼻通气功能指标的相关性。结果:PAR组血清hs-CRP、IL-1β、IL-6及IL-8水平及SFAR评分、VAS评分、NAR均明显高于正常组(P<0.05),NCV0~5、NMCA及NS均明显低于正常组(P<0.05)。中重度组的血清hs-CRP、IL-1β、IL-6及IL-8水平及SFAR评分、VAS评分、NAR均明显高于轻度组(P<0.05),NCV0~5、NMCA及NS均明显低于轻度组(P<0.05)。各组之间血清PCT水平比较差异无统计学意义(P>0.05);血清hs-CRP、IL-1β、IL-6及IL-8水平与SFAR评分、VAS评分、NAR均呈明显正相关(P<0.05),与NCV0~5、NMCA及NS均呈明显负相关(P<0.05)。结论:血清hs-CRP、IL-1β、IL-6及IL-8水平随着儿童PAR病情加重而明显增高,对儿童PAR的病情严重程度及鼻通气功能评估中具有一定的价值。Objective:To investigate the relationship between the level of serum inflammatory factors in children with perennial allergic rhinitis(PAR)and the severity degree of illness and nasal ventilation function.Method:A total of 100 cases of PAR children admitted to Baoding Children's Hospital from July 2020 to June 2021 were continuously included as PAR group,and the children were divided into mild group(n=48)and moderate and severe group(n=52)according to"Clinical Practice Guidelines for the Diagnosis and Treatment of Allergic rhinitis in Children",and 50 healthy children in the same period were taken as normal group.The levels of serum inflammatory cytokines[hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT),interleukin-1β(IL-1β),interleukin-6(IL-6)and interleukin-8(IL-8)],disease evaluation indexes[score for allergic rhinitis(SFAR)score and symptom visual analogue scale(VAS)score]and nasal ventilation function indexes[nasal airway resistance(NAR),0-5 cm nasal cavity volume(NCV0-5),nasal minimum crosssectional area(NMCA),nasal spirometry(NS)]in each group were compared.Pearson correlation coefficient was used to analyze the correlation between serum inflammatory factors,disease evaluation indicators and nasal ventilation function indicators.Result:The levels of serum hs-CRP,IL-1β,IL-6 and IL-8,SFAR score,VAS score and NAR in PAR group were significantly higher than those in normal group(P<0.05),while NCV0-5,NMCA and NS in PAR group were significantly lower than those in normal group(P<0.05).Serum levels of hs-CRP,IL-1β,IL-6 and IL-8,SFAR score,VAS score and NAR in moderate to severe group were significantly higher than those in mild group(P<0.05),while NCV0-5,NMCA and NS were significantly lower than those in mild group(P<0.05).There were no significant differences in serum PCT level among all groups(P>0.05).Serum hs-CRP,IL-1β,IL-6 and IL-8 levels were positively correlated with SFAR score,VAS score and NAR(P<0.05),and negatively correlated with NCV0-5,NMCA and NS(P<0.05).Conclusion:Serum levels of hs

关 键 词：常年性过敏性鼻炎 儿童 炎症因子 病情严重程度 鼻通气功能 相关性 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]