瓜蒌薤白桂枝汤合丹参饮联合西医规范治疗痰浊血瘀型稳定型心绞痛的效果  

Effect of Gualou Xiebai Guizhi Decoction and Danshen Decoction Combined with Western Standard Treatment in theTreatment of Phlegm-turbidity-blood-stasis Type of Stable Angina Pectoris

作　　者：李红萍 LI Hongping(Huairou Hospital,Beijing Chaoyang Hospital,Capital Medical University,Beijing 101400,China)

机构地区：[1]首都医科大学附属北京朝阳医院怀柔医院,北京101400

出　　处：《中外医学研究》2023年第9期9-12,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨瓜蒌薤白桂枝汤合丹参饮联合西医规范治疗痰浊血瘀型稳定型心绞痛(SAP)的效果。方法:选取2021年4月—2022年3月首都医科大学附属北京朝阳医院怀柔医院心内科收治的96例痰浊血瘀型SAP患者,根据电脑随机数分为试验组(n=48)与对照组(n=48)。对照组给予西医规范治疗,试验组在对照组基础上给予瓜蒌薤白桂枝汤合丹参饮,两组均治疗4周。比较两组中医症候积分变化、临床疗效、硝酸甘油停药情况、自主神经功能变化及安全性。结果:治疗后,两组中医症候积分低均于治疗前,且试验组低于对照组,差异均有统计学意义(P<0.05);试验组临床总有效率为93.75%,高于对照组的77.08%,差异有统计学意义(P<0.05);治疗后,两组硝酸甘油服用量较治疗前均减少,且试验组少于对照组,差异均有统计学意义(P<0.05)。治疗后,两组正常R-R间期总标准差(SDNN)、每5分钟R-R间期标准差均值(SDNN5)均大于治疗前,且试验组大于对照组,差异均有统计学意义(P<0.05);治疗后,试验组SDANN大于治疗前及对照组,差异均有统计学意义(P<0.05)。两组治疗期间均未出现毒副作用。结论:瓜蒌薤白桂枝汤合丹参饮联合西医规范治疗痰浊血瘀型SAP患者效果显著,降低中医症候积分,改善自主神经功能,减少硝酸甘油用药,安全可靠。Objective:To investigate the effect of Gualou Xiebai Guizhi Decoction and Danshen Decoction combined with western standard treatment in the treatment of phlegm-turbidity-blood-stasis type of stable angina pectoris(SAP).Method:From April 2021 to March 2022,96 patients with phlegm-turbidity-blood-stasis type of SAP who admitted to the Department of Cardiology of Huairou Hospital,Beijing Chaoyang Hospital,Capital Medical University were selected and divided into the experimental group(n=48)and the control group(n=48)according to computer random numbers.The control group was given standard western medicine treatment,and the experimental group was given Gualou Xiebai Guizhi Decoction and Danshen Decoction on the basis of the control group,two groups were treated for 4 weeks.The changes of traditional Chinese medicine(TCM)symptom score,clinical efficacy,nitroglycerin withdrawal,autonomic nervous function changes and safety were compared between two groups.Result:After treatment,the TCM syndrome scores in two groups were lower than those before treatment,and the experimental group was lower than the control group,the differences were statistically significant(P<0.05).The total clinical effective rate of the experimental group was 93.75%,which was higher than 77.08%of the control group,the difference was statistically significant(P<0.05).After treatment,the dosage of nitroglycerin in two groups were decreased compared with those before treatment,and the experimental group was less than that of the control group,the differences were statistically significant(P<0.05).After treatment,the total standard deviation of normal R-R interval(SDNN)and mean standard deviation of R-R interval every 5 minutes(SDNN5)in two groups were higher than those before treatment,and the experimental group was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,the SDANN in the experimental group was greater than those before treatment and the control group,the differences were statisticall

关 键 词：稳定型心绞痛 痰浊血瘀 瓜蒌薤白桂枝汤合丹参饮 自主神经功能 

分 类 号：R541.4[医药卫生—心血管疾病]