An Innovative Bispectral Deep Learning Method for Protein Family Classification  

作　　者：Isam Abu-Qasmieh Amjed Al Fahoum Hiam Alquran Ala’a Zyout 

机构地区：[1]Biomedical Systems and Informatics Engineering Department,Hijjawi Faculty for Engineering Technology,Yarmouk University,Irbid,21163,Jordan

出　　处：《Computers, Materials & Continua》2023年第5期3971-3991,共21页计算机、材料和连续体（英文）

摘　　要：Proteins are essential for many biological functions.For example,folding amino acid chains reveals their functionalities by maintaining tissue structure,physiology,and homeostasis.Note that quantifiable protein characteristics are vital for improving therapies and precision medicine.The automatic inference of a protein’s properties from its amino acid sequence is called“basic structure”.Nevertheless,it remains a critical unsolved challenge in bioinformatics,although with recent technological advances and the investigation of protein sequence data.Inferring protein function from amino acid sequences is crucial in biology.This study considers using raw sequencing to explain biological facts using a large corpus of protein sequences and the Globin-like superfamily to generate a vector representation.The power of two representations was used to identify each amino acid,and a coding technique was established for each sequence family.Subsequently,the encoded protein numerical sequences are transformed into an image using bispectral analysis to identify essential characteristics for discriminating between protein sequences and their families.A deep Convolutional Neural Network(CNN)classifies the resulting images and developed non-normalized and normalized encoding techniques.Initially,the dataset was split 70/30 for training and testing.Correspondingly,the dataset was utilized for 70%training,15%validation,and 15%testing.The suggested methods are evaluated using accuracy,precision,and recall.The non-normalized method had 70%accuracy,72%precision,and 71%recall.68%accuracy,67%precision,and 67%recall after validation.Meanwhile,the normalized approach without validation had 92.4%accuracy,94.3%precision,and 91.1%recall.Validation showed 90%accuracy,91.2%precision,and 89.7%recall.Note that both algorithms outperform the rest.The paper presents that bispectrum-based nonlinear analysis using deep learning models outperforms standard machine learning methods and other deep learning methods based on convolutional architectu

关 键 词：Globin-like superfamily numerical encoding bispectral analysis classification model deep convolutional neural network(CNN) 

分 类 号：TP18[自动化与计算机技术—控制理论与控制工程]