赖氏通元针灸疗法联合丁苯酞治疗脑梗死的临床疗效观察  

Clinical Observation of LAI’s Tongyuan Acupuncture-Moxibustion Therapy Combined with Butylphthalide Capsules in the Treatment of Cerebral Infarction

作　　者：刘晓娜 杨瑾翀 林畅 余瑾[2] 李莉 LIU Xiao-Na;YANG Jin-Chong;LIN Chang;YU Jin;LI Li(People's Hospital of Chenghai Shantou,Guangzhou 515800 Guangdong,China;Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Guangdong Food and Drug Vocational College,Guangzhou 510520 Guangdong,China)

机构地区：[1]广东省汕头市澄海区人民医院,广东汕头515800 [2]广州中医药大学,广东广州510006 [3]广东省食品药品职业学院,广东广州510520

出　　处：《广州中医药大学学报》2023年第4期904-910,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：汕头市科技计划资助项目(编号:210206156490123);广东省教育厅广东省高校科研平台资助项目(编号:2019KZDZX1041)。

摘　　要：【目的】观察赖氏通元针灸疗法联合丁苯酞治疗脑梗死的临床疗效。【方法】将64例脑梗死患者随机分为观察组和对照组,每组各32例。对照组给予丁苯酞软胶囊口服,观察组在对照组治疗的基础上,给予赖氏通元针灸疗法治疗。连续治疗7 d。治疗1周后,评价2组临床疗效,观察2组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)、神经功能缺损程度量表(NFDS)评分的变化情况,以及日常生活能力评定量表(Barthel指数)评分的情况。比较2组患者治疗前后炎症因子超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)、脂蛋白相关磷脂酶(Lp-PLA2)水平的变化情况。并评价2组的安全性及不良反应的发生情况。【结果】(1)治疗后,2组患者的NIHSS、NFDS评分明显改善(P<0.05),且观察组在改善NIHSS、NFDS评分方面明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的hs-CRP、MMP-9、Lp-PLA2水平均明显改善(P<0.05),且观察组在改善hs-CRP、MMP-9、Lp-PLA2水平方面均明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的日常生活能力量表评分明显改善(P<0.05),且观察组在改善日常生活能力量表评分方面明显优于对照组,差异有统计学意义(P<0.05)。(4)观察组总有效率为93.75%(30/32),对照组为71.88%(23/32)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(5)观察组不良反应发生率为9.38%(3/32),对照组为32.26%(10/32)。观察组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。【结论】赖氏通元针灸疗法联合丁苯酞治疗脑梗死,能明显改善患者的临床症状,提高患者日常生活能力,从而提高患者生活质量,疗效显著。Objective To observe the clinical efficacy of LAI’s Tongyuan Acupuncture-Moxibustion Therapy(an acupuncture therapy for dreging the governer vessel to regulate mind and conducting qi back to its source)combined with Butylphthalide Capsules in the treatment of rcerebral infarction. Methods Sixty-four patients with cerebral infarction were randomly divided into the observation group and the control group,with 32 patients in each group.The control group was given oral use of Butylphthalide Capsules,while the observation group was given LAI’s Tongyuan Acupuncture-Moxibustion Therapy on top of the control group. After one week of treatment,the clinical efficacy of the two groups was evaluated,and the changes in the National Institutes of Health Stroke Scale(NIHSS)and Neurological Function Deficit Scale(NFDS)scores,as well as the Barthel Index scores were observed before and after treatment in the two groups. The changes in the levels of inflammatory factors hypersensitive C-reactive protein(hs-CRP),matrix metalloproteinase-9(MMP-9)and lipoprotein-associated phospholipase(Lp-PLA2)were compared before and after treatment in the two groups. The safety of the two groups and the occurrence of adverse reactions were also evaluated. Results(1)After treatment,the NIHSS and NFDS scores of patients in the two groups were significantly improved(P<0.05), and the observation group was significantly superior to the control group in improving the NIHSS and NFDS scores,the difference being statistically significant(P<0.05).(2)After treatment,the levels of hs-CRP,MMP-9 and Lp-PLA2 in both groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving the levels of hsCRP,MMP-9 and Lp-PLA2,the difference being statistically significant(P<0.05).(3)After treatment,the scores of daily living ability scale score of the two groups were significantly improved(P<0.05), and the observation group was significantly superior to the control group in improving the scores of daily

关 键 词：赖氏通元疗法 针灸 丁苯酞 脑梗死 临床疗效 

分 类 号：R246.9[医药卫生—针灸推拿学]