通阳宽胸颗粒对稳定性冠心病患者炎症因子和脂蛋白α的影响  

Effects of Tongyang Kuanxiong Granules on Inflammatory Factors and Lipoprotein Alpha in Patients with Stable Coronary Artery Disease

作　　者：吴庆湘 蔡伟才 张松杰 林剑良 梁满光 袁丁[2] WU Qing-Xiang;CAI Wei-Cai;ZHANG Song-Jie;LIN Jian-Liang;LIANG Man-Guang;YUAN Ding(The Fifth Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou 510095 Guangdong,China)

机构地区：[1]广州中医药大学第五临床医学院,广东广州510405 [2]广东省第二中医院,广东广州510095

出　　处：《广州中医药大学学报》2023年第3期570-575,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20201016)。

摘　　要：【目的】探讨通阳宽胸颗粒(由瓜蒌皮、桂枝、薤白等中药组成)对稳定性冠心病(SCAD)气虚血瘀证患者的疗效及对炎症因子和脂蛋白α[Lp(α)]水平的影响。【方法】将80例SCAD气虚血瘀证患者随机分为观察组和对照组,每组各40例。对照组给予常规西药治疗,观察组在对照组的基础上联合通阳宽胸颗粒治疗,疗程为4周。观察2组患者治疗前后血清白细胞介素6(IL-6)、白细胞介素17(IL-17)、超敏C反应蛋白(hs-CRP)、脂蛋白α[Lp(α)]的变化情况,并评估2组患者的心绞痛疗效、负荷心电图疗效、中医证候疗效和安全性。【结果】(1)心绞痛疗效方面:治疗4周后,观察组的显效率和总有效率分别为47.5%(19/40)、77.50%(31/40),对照组分别为20.0%(8/40)、75.0%(30/40);组间比较,观察组的显效率和总体疗效均优于对照组(P<0.05)。(2)中医证候疗效方面:治疗4周后,观察组的显效率和总有效率分别为47.5%(19/40)、80.0%(32/40),对照组分别为25.0%(10/40)、57.5%(23/40);组间比较,观察组的显效率、总有效率和总体疗效均优于对照组(P<0.05)。(3)负荷心电图疗效方面:治疗4周后,观察组的负荷心电图总阳性率为47.5%(19/40),明显低于对照组的75.0%(30/40),差异有统计学意义(P<0.05),表明观察组的负荷心电图疗效优于对照组。(4)实验室指标方面:治疗后,2组患者血清IL-6、IL-17、hs-CRP、Lp(α)水平均较治疗前明显降低(P<0.05),且观察组的降低作用均明显优于对照组,差异均有统计学意义(P<0.05)。(5)安全性方面:治疗过程中,2组患者均未见明显毒副反应,且2组患者的血、尿、大便常规及肝肾功能等安全性指标均无异常改变。【结论】通阳宽胸颗粒对SCAD气虚血瘀证患者有较好疗效,可有效改善炎症因子及Lp(α)水平。Objective To investigate the clinical efficacy of Tongyang Kuanxiong Granules(mainly composed of Trichosanthis Pericarpium, Cinnamomi Ramulus and Allii Macrostemonis Bulbus) for patients with stable coronary artery disease(SCAD)of qi deficiency and blood stasis syndrome,and to observe their effects on the levels of inflammatory factors and lipoprotein alpha [Lp(α)]. Methods Eighty cases of SCAD of qi deficiency and blood stasis syndrome were randomly divided into the observation group and the control group,with 40 cases in each group. The control group was given conventional western medicine treatment,while the observation group was treated with Tongyang Kuanxiong Granules on the basis of treatment for the control group. Both groups were treated for a period of 4 weeks. The changes in serum levels of interleukin 6(IL-6), interleukin 17(IL-17),hypersensitive C-reactive protein(hs-CRP)and Lp(α)in the two groups before and after treatment were observed.Furthermore,the efficacy of angina pectoris,the efficacy of stress electrocardiogram,the efficacy of traditional Chinese medicine(TCM)syndrome and clinical safety in the two groups were evaluated. Results(1)After 4 weeks of treatment, the markedly effective rate and overall effective rate for the efficacy of angina pectoris in the observation group were 47.5%(19/40)and 77.50%(31/40)respectively, and those in the control group were20.0%(8/40)and 75.0%(30/40)respectively. The intergroup comparison showed that the marked effective rate and overall efficacy of the observation group were better than those of the control group(P<0.05).(2)After 4 weeks of treatment,the marked effective rate and total effective rate for the efficacy of TCM syndrome in the observation group were 47.5%(19/40)and 80.0%(32/40)respectively,and those in the control group were 25.0%(10/40)and 57.5%(23/40)respectively in the control group. The intergroup comparison showed that the marked effective rate,total effective rate and overall efficacy of the observation group were superior to those of the

关 键 词：通阳宽胸颗粒 稳定性冠心病 气虚血瘀证 炎症因子 脂蛋白Α 

分 类 号：R259.414[医药卫生—中西医结合]