平调颗粒对肝阳上亢型原发性高血压患者生活质量的影响  

Effect of Pingtiao Granules on the Quality of Life of Patients with Essential Hypertension of Ascendant Hyperactivity of Liver Yang Syndrome

作　　者：邓慧芳 张六燕 冯彩玲 靳利利[2] 史振羽[2] 袁丁[2] DENG Hui-Fang;ZHANG Liu-Yan;FENG Cai-Ling;JIN Li-Li;SHI Zheng-Yu;YUAN Ding(The Fifth Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou 510095 Guangdong,China)

机构地区：[1]广州中医药大学第五临床医学院,广东广州510405 [2]广东省第二中医院,广东广州510095

出　　处：《广州中医药大学学报》2023年第3期576-581,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20201016)。

摘　　要：【目的】观察平调颗粒(在天麻钩藤饮的基础上加减而成)治疗肝阳上亢型原发性高血压的临床疗效及其对患者生活质量的影响。【方法】将80例肝阳上亢型原发性高血压患者随机分为治疗组和对照组,每组各40例。对照组给予高血压患者健康教育以及口服缬沙坦胶囊治疗,治疗组在对照组的基础上加用中药平调颗粒治疗,疗程为8周。观察2组患者治疗前后血压、中医证候积分及杜氏高血压生活质量量表评分的变化情况,并评价2组患者的降压疗效、中医证候疗效及安全性。【结果】(1)血压方面:治疗后,2组患者的收缩压(SBP)、舒张压(DBP)水平均较治疗前降低(P<0.05),且治疗组的降压效果均明显优于对照组(P<0.05)。(2)降压疗效方面:治疗8周后,治疗组的总有效率为90.0%(36/40),对照组为75.0%(30/40),组间比较,治疗组的降压疗效优于对照组(P<0.05)。(3)中医证候疗效方面:治疗8周后,治疗组的总有效率为90.0%(36/40),对照组为62.5%(25/40),组间比较,治疗组的中医证候疗效明显优于对照组(P<0.05)。(4)生活质量方面:经杜氏高血压生活质量量表评分,治疗8周后,除人际关系敏感评分未见显著性差异(P>0.05)外,2组患者的生理症状、躯体化症状、性功能失调、睡眠状况、生气或活力、焦虑、压抑、强迫状态、工作状态及敌对等各个维度评分均较治疗前提高(P<0.05),且治疗组对生理症状、躯体化症状、性功能失调、睡眠状况、生气或活力、焦虑及压抑评分的提高作用均明显优于对照组,差异均有统计学意义(P<0.05),而2组对强迫状态、工作状态、敌对及人际关系敏感评分的提高作用均无显著性差异(P>0.05)。(5)安全性方面:治疗过程中,2组患者均无明显不良反应发生,具有较高的安全性。【结论】中药平调颗粒对肝阳上亢型原发性高血压患者的降压疗效确切,能显著提高患者生活质量,主要体现在对Objective To investigate the clinical efficacy of Pingtiao Granules(derived from the modification of Tianma Gouteng Decoction)on essential hypertension(ES)with ascendant hyperactivity of liver yang syndrome and to observe their influence on patients’ quality of life. Methods Eighty patients with primary hypertension of the liver-yang hyperactivity type were randomly divided into the treatment group and the control group,with 40 cases in each group. The control group was given health education together with oral use of Valsartan Capsules,while the treatment group was treated with Chinese herbal medicine Pingtiao Granules based on the treatment for the control group. Both groups were treated for 8 weeks. The changes in blood pressure,traditional Chinese medicine(TCM)syndrome score and Duchenne Hypertension Quality of Life Scale scores in the two groups were observed before and after treatment,and then the antihypertensive efficacy,TCM syndrome efficacy and safety of the patients in the two groups were also evaluated. Results(1)After treatment,the systolic blood pressure(SBP)and diastolic blood pressure(DBP)levels of both groups were decreased compared with those before treatment(P<0.05),and the antihypertensive effect of the treatment group was significantly superior to that of the control group(P<0.05).(2)After 8 weeks of treatment,the overall effective rate for antihypertensive efficacy in the treatment group was90.0%(36/40)and that in the control group was 75.0%(30/40). The intergroup comparison showed that the antihypertensive efficacy in the treatment group was superior to that in the control group(P<0.05).(3)After8 weeks of treatment, the overall effective rate for TCM syndrome efficacy in the treatment group was 90.0%(36/40),and that in the control group was 62.5%(25/40). The intergroup comparison showed that the efficacy of TCM syndrome in the treatment group was significantly superior to that in the control group(P<0.05).(4)As for the quality of life,except that the scores of interpersonal sensitivity di

关 键 词：平调颗粒 天麻钩藤饮 肝阳上亢型 原发性高血压 生活质量 

分 类 号：R259.441[医药卫生—中西医结合]