硫酸软骨素蛋白聚糖的研究进展  

Research Progress of Chondroitin Sulfate Proteoglycans

作　　者：司雨 房俊强[2] 高向东 刘玮 SI Yu;FANG Junqiang;GAO Xiangdong;LIU Wei(Jiangsu Key Laboratory of Druggability of Biopharmaceuticals,School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China;Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University,Qingdao 266200,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏省生物药物成药性研究重点实验室,江苏南京211198 [2]山东大学山东省糖化学与生物学重点实验室,山东青岛266200

出　　处：《药学进展》2023年第2期125-134,共10页Progress in Pharmaceutical Sciences

基　　金：国家重点研发计划(No.2018YFA0902000);江苏省自然科学基金(No.BK20191317);山东大学山东省糖化学与生物学重点实验室开放课题(No.2021CCG04)。

摘　　要：硫酸软骨素蛋白聚糖(CSPGs)是硫酸软骨素(CS)和核心蛋白共价连接的糖复合物,存在于细胞表面和结缔组织中。近年来,CSPGs领域快速发展,CSPGs不仅作为软骨、椎间盘、脑和角膜等复杂基质的结构成分发挥作用,还可作用于多种生物活性分子,参与血管生成、炎症反应、肿瘤发生以及神经的发育和修复等生理病理过程。研究表明,CS糖链的种类、相对分子质量以及硫酸化程度等均会影响CSPGs的生物学功能。此外,CSPGs已被认为是肿瘤、中枢神经系统损伤等疾病治疗的靶点以及诊断潜在的生物标志物。按照CSPGs在细胞中的定位,对典型CSPGs的结构、功能及其作为疾病诊断和治疗靶点等生物学意义的最新研究进展进行综述,旨在为CSPGs在疾病治疗中的应用提供参考。Chondroitin sulfate proteoglycans(CSPGs),which are glycoconjugates covalently linked by chondroitin sulfate(CS)and core protein,exist on the cell surface and connective tissues.With the rapid development of the field of CSPGs in recent years,CSPGs are not only considered as structural components of complex matrix such as cartilage,intervertebral discs,brain,and cornea,they can also interact with various bioactive molecules and participate in physiopathological processes such as angiogenesis,inflammatory responses,tumorigenesis,and neurodevelopment.Studies have shown that the type,molecular weight,and sulfation degree of CS glycans would affect the biological function of CSPGs.In addition,CSPGs have been considered as therapeutic targets and potential diagnostic biomarkers of diseases such as cancer and central nervous system injury.According to the location of CSPGs in cells,this article reviews the recent advances in the structure and function of typical CSPGs as well as their biological significance as targets for disease diagnosis and treatment,aiming to provide reference for promoting the application of CSPGs in disease therapy.

关 键 词：硫酸软骨素蛋白聚糖 糖胺聚糖 肿瘤发生 神经发育 

分 类 号：Q539[生物学—生物化学]