间充质干细胞与巨噬细胞相互作用机制的研究进展  

Research progress in the interaction mechanism between mesenchymalstem cells and macrophages

作　　者：陈彤 张帆[1] 房橙橙 李全海[1,2] 闫宝勇[1] 张君[1] Chen Tong;Zhang Fan;Fang Chengcheng;Li Quanhai;Yan Baoyong;Zhang Jun(Laboratory of Cell Therapy,First Hospital of Hebei Medical University,Shijiazhuang 050030,China;Department of Immunology,Hebei Medical University,Shijiazhuang 050011,China)

机构地区：[1]河北医科大学第一医院细胞治疗实验室,石家庄050030 [2]河北医科大学免疫教研室,石家庄050011

出　　处：《中华细胞与干细胞杂志（电子版）》2022年第6期372-377,共6页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：河北省自然科学基金资助(C2020206032);温州市重大科技创新攻关项目资助(ZY2022027)。

摘　　要：间充质干细胞(MSCs)主要通过旁分泌作用于免疫细胞而参与组织修复与重塑。巨噬细胞具有吞噬杀伤和免疫调节功能,与组织细胞协调应对病理和生理应激。在炎症反应中,MSCs能借助多种方式使促炎的M1型巨噬细胞向抗炎的M2型巨噬细胞转化,调控炎症因子、抑制炎症反应和减少组织细胞损伤;同时,炎症微环境中的巨噬细胞释放多种因子也对MSCs的生物学功能产生影响。本文综述了MSCs和巨噬细胞相互作用机制及双方信息交换的研究进展,涉及细胞因子分泌、旁分泌和细胞间直接接触等方式,为优化MSCs生物学功能、修复炎症性组织损伤提供策略和方案。Mesenchymal stem cells(MSCs)mainly act on immune cells through the paracrine and participate in tissue repair and remodelling.Macrophages have the functions of phagocytosis and immune regulation and coordinate with many types of cells to cope with pathophysiological stress.In the inflammatory response,MSCs transform pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages in a variety of ways,regulate inflammatory factors,inhibit inflammatory responses and reduce tissue cell damage;At the same time,the release of multiple factors by macrophages in the inflammatory microenvironment also affects the biological function of MSCs.This review summarises the interaction mechanism between MSCs and macrophages,and the latest research progress in their information exchange,involving cytokine secretion,paracrine and intercellular direct contact.It will provide the strategy and scheme for optimizing MSCs'function to repair inflammatory tissue damage.

关 键 词：间充质干细胞 巨噬细胞 炎症反应 相互作用机制 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]