多取代2,3-二氢-4-吡啶酮的水相合成  

Synthesis of Polysubstituted 2,3-Dihydropyridin-4(1H)-one in Water

作　　者：王维 张哲宇 张雪 于海丰 罗辉 霍东月 徐玉澎 赵晓波 Wang Wei;Zhang Zheyu;Zhang Xue;Yu Haifeng;Luo Hui;Huo Dongyue;Xu Yupeng;Zhao Xiaobo(College of Chemistry,Baicheng Normal University,Baicheng,Jilin 137000)

机构地区：[1]白城师范学院化学学院,吉林白城137000

出　　处：《有机化学》2023年第2期742-750,共9页Chinese Journal of Organic Chemistry

基　　金：吉林省自然科学基金(No.20210101128JC);吉林省教育厅科学技术基金(No.JJKH20200001KJ)资助项目。

摘　　要：首次探讨了α-烯酰基二硫缩烯酮与胺的[5C+1N]水相环合反应,成功地实现多取代2,3-二氢-4-吡啶酮的水相合成.研究表明,在回流水中,(E)-2-(二乙硫基)亚甲基-3-羰基-5-芳基-N-芳基戊-4-烯酰胺1和有机胺2有效地发生[5C+1N]水相环合反应,以较好产率合成多取代2,3-二氢-4-吡啶酮3.For the first time,the aqueous[5C+1N]annulation ofα-alkenoyl ketene dithioacetals and amines for the synthesis of polysubstituted 2,3-dihydropyridin-4(1H)-ones was developed.In boiling water,[5C+1N]annulation of(E)-2-(bis(ethylthio)methylene)-3-oxo-N,5-diarylpent-4-enamides 1 and organic amines 2 smoothly occurred,and polysubstituted 2,3-dihydropyridin-4(1H)-ones 3 was obtained in moderate yields.

关 键 词：水相反应 二硫缩烯酮 胺 吡啶酮 

分 类 号：O626[理学—有机化学]