长叶暗罗中克罗烷型二萜及其抗炎作用  

Anti-inflammatory Clerodane Diterpenoids from Polyalthia longifolia

作　　者：余章昕[1,2] 宋鑫明[1,2] 姚远 杨俊 杨硕 李小宝[1,2] Yu Zhangxin;Song Xinming;Yao Yuan;Yang Jun;Yang Shuo;Li Xiaobao(Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,Hainan Normal University,Haikou 571158;Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158)

机构地区：[1]海南师范大学、热带药用资源化学教育部重点实验室,海口571158 [2]海南师范大学化学与化工学院、热带药用植物化学海南省重点实验室,海口571158

出　　处：《有机化学》2023年第2期751-755,共5页Chinese Journal of Organic Chemistry

基　　金：海南省自然科学基金(Nos.221MS034,220MS036);海南省重点研发(Nos.ZDYF2022SHFZ286,ZDYF2021SHFZ072);海南省教育厅(No.Hnky 2021-30);国家自然科学基金(No.21662012);海南省院士创新平台(No.YSPTZX202030);中央引导地方科技发展资金(No.ZY2022HN08)资助项目。

摘　　要：对长叶暗罗茎的化学成分进行研究,分离得到4个新的克罗烷型二萜类化合物,通过NMR、HR-ESI-MS等多种现代波谱技术鉴定为:2-氧代-14,15,16-降三碳克罗烷-3-烯-13-酸(1)、2-氧代-14,15,16-降三碳克罗烷-3-烯-13-甲酯(2)、2-氧代-14,15,16-降三碳克罗烷-3,11E-二烯-13-酸(3)、2-氧代-16-羟基-克罗烷-3,13Z-二烯-15-酸(4).其中,化合物1~3为降三碳克罗烷型二萜,所有化合物均表现出一定的抗炎活性,IC_(50)值范围为9.24~18.82μmol/L.Four new clerodane diterpenoids(1~4)were obtained from the stems of Polyalthia longifolia during a systematic phytochemical investigation.Their structures were elucidated comprehensive spectroscopic methods as 2-oxo-14,15,16-trinorclerod-3-en-13-oic acid(1),2-oxo-14,15,16-trinorclerod-3-en-13-methyl ester(2),2-oxo-14,15,16-trinorclerod-3,11Edien-13-oic acid(3),and 2-oxo-cleroda-3,13Z-dien-16-hydroxy-15-oic acid(4).Among them,compounds 1~3 are 14,15,16-norclerodane diterpenoids.The anti-inflammatory activity of mouse leukemia cells of monocyte macrophage(RAW 264.7)cells with lipopolysaccharide-induced was evaluated,and all the compounds showed potential anti-inflammatory activities with IC_(50)values ranged from 9.24 to18.82μmol/L.

关 键 词：长叶暗罗 克罗烷型二萜 抗炎活性 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]