α-酮酸与硫酚的电化学脱羧偶联:一种合成硫代酸酯的新方法  

Electrochemical Decarboxylation Coupling ofα-Keto Acids with Thiophenols:A New Avenue for the Synthesis of Thioesters

作　　者：黄嘉为 李潇漫 徐亮[1] 韦玉[1] Huang Jiawei;LiXiaoman;Xu Liang;Wei Yu(Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan,School of Chemistry and Chemical Engineering,Shihezi University,Shihezi,Xinjiang 832003)

机构地区：[1]石河子大学化学化工学院、新疆兵团化工绿色过程重点实验室,新疆石河子832003

出　　处：《有机化学》2023年第2期756-762,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.22061036)资助项目。

摘　　要：在生物活性分子、天然产物和有机材料的合成中,硫酯类化合物为常见的反应中间体.近些年来,α-酮酸与硫醇或硫酚的脱羧偶联成为合成该类化合物的新方法,实现了电化学条件下α-酮酸与硫酚的脱羧偶联反应,以中等至良好的收率得到硫酯类化合物.该方法操作简便,无需传统方法中的常用的金属催化剂、碱或外部氧化剂,为硫酯类化合物的合成提供了一条温和、绿色的新路径.Thioester compounds have been widely applied in the synthesis of bioactive chemicals,natural products and organic materials due to their versatile reactivities.In recent years,the decarboxylation coupling reactions betweenα-keto acids and thiols/thiophenols have been utilized to access thioesters.Herein,an electrochemical decarboxylation coupling method has been established,which usesα-keto acids and thiophenols as the starting materials and affords thioesters in moderate to good yields.This protocol features simple manipulation and avoids usually needed metal-based catalysts,bases or external oxidants,thus providing a new,mild,and green pathway to synthesize thioester compounds.

关 键 词：电化学合成 Α-酮酸 硫酚 硫酯 

分 类 号：TQ227.4[化学工程—有机化工]