A novel MgF2/PDA/S-HA coating on the bio-degradable ZE21B alloy for better multi-functions on cardiovascular application  

作　　者：Yang Yu Shi-Jie Zhu Hao-Tian Dong Xue-Qi Zhang Jing-An Li Shao-Kang Guan 

机构地区：[1]School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education),Zhengzhou University,Zhengzhou 450001,China

出　　处：《Journal of Magnesium and Alloys》2023年第2期480-492,共13页镁合金学报（英文）

基　　金：funded by the Key Projects of the Joint Fund of the National Natural Science Foundation of China(U1804251);National Key Research and Development Program of China (2017YFB0702500, 2018YFC1106703, and 2016YFC1102403);Top Doctor Program of Zhengzhou University (grant number 32210475)。

摘　　要：Recently, functional molecules such as Polydopamine(PDA), Hyaluronic Acid(HA) and heparin have been widely studied in the field of surface modification of magnesium(Mg) alloy stents for better degradation behavior and biocompatibility, but their further application is limited by undesirable anticoagulant function, uncontrollable degradation and easy bleeding, respectively.Regarding to this consideration, a magnesium Fluoride/Polydopamine/Sulphonated hyaluronic acid(Mg F2/PDA/S-HA) composite coating was successfully prepared by applying S-HA with sulfur content of 9.71 wt% on the surface of ZE21B alloy in this study. The results showed that the composite coating with a unique mesh structure not only inherited the anticoagulant effect of sulfonic acid group and the excellent cyto-compatibility of S-HA with high sulfur content, but also significantly improved the corrosion performance of ZE21B alloy.These results indicate a great application potential of the composite coating in the field of cardiovascular biomaterials.

关 键 词：Bio-degradable magnesium alloy Cardio-vascular stents Composite coating Sulphonated hyaluronic acid 

分 类 号：TG146[一般工业技术—材料科学与工程]