Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release  

作　　者：Qiangbing WEI Tian FU Lele LEI Huan LIU Yixin ZHANG Shuanhong MA Feng ZHOU 

机构地区：[1]Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education,Key Laboratory of Polymer Materials of Gansu Province,College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070,China [2]State Key Laboratory of Solid Lubrication,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China [3]Shandong Laboratory of Yantai Advanced Materials and Green Manufacture,Yantai 264006,China

出　　处：《Friction》2023年第3期410-424,共15页摩擦（英文版）

基　　金：This work was financially supported by National Natural Science Foundation of China(52065061,22032006);Outstanding Youth Fund of Gansu Province(21JR7RA158,21JR7RA095);Innovation Fund for Universities of Gansu Province(2021A-015);Youth Innovation Promotion Association CAS(2019411).

摘　　要：Osteoarthritis(OA)has been regarded as a lubrication deficiency related joint disease.Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA.Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required.Herein,dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt)(PDA-PSPMA)conjugate coating on hollow silica(h-SiO_(2))nanosphere surfaces to engineer functional nanoparticles(h-SiO_(2)/PDA-PSPMA).The as-prepared h-SiO_(2)/PDA-PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA-PSPMA coating and"rolling"effect of h-SiO_(2)nanospheres.In vitro drug loading-release experiments demonstrate that PDA-PSPMA coating functionalized h-SiO_(2)nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug,diclofenac sodium(DS).Such h-SiO_(2)/PDA-PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication anddrugrelease.

关 键 词：osteoarthritis treatment functionalized nanoparticles injectable biolubricant friction reduction drug release 

分 类 号：TQ427.26[化学工程] TQ460.4