颈动脉斑块的流固耦合数值模拟  

Fluid-Structure Interaction Simulation of Carotid Plaque

作　　者：万栋栋 何鹏 张武[1,3] 高晓龙 谢江 WAN Dongdong;HE Peng;ZHANG Wu;GAO Xiaolong;XIE Jiang(School of Mechanics and Engineering Science,Shanghai University,Shanghai 200072,China;School of Computer Engineering and Science,Shanghai University,Shanghai 200072,China;Shanghai Institute of Applied Mathematics and Mechanics,Shanghai University,Shanghai 200072,China;Department of Radiology,Luodian Hospital of Shanghai Baoshan District,Shanghai 201908,China)

机构地区：[1]上海大学力学与工程科学学院,上海200072 [2]上海大学计算机科学与工程学院,上海200072 [3]上海大学上海市应用数学和力学研究所,上海200072 [4]上海宝山区罗店医院放射科,上海201908

出　　处：《医用生物力学》2023年第1期116-122,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(61873156)。

摘　　要：目的 提出一种基于真实颈动脉狭窄患者的双向流固耦合计算方法,用于分析不同类型颈动脉斑块在病变处的血流动力学参数以及斑块自身的变形和应力变化。方法 对颈动脉中度狭窄病人CT血管造影数据进行3D建模,分离出颈动脉血管壁模型和斑块模型,并进行瞬态流固耦合计算。模拟颈动脉粥样硬化的早期到形成斑块,将斑块类型分为增厚斑块、脂质斑块、混合斑块和钙化斑块,其中增厚斑块视为无斑块的情况,代表血管内膜-中膜的增厚,并对不同斑块类型的狭窄颈动脉进行对比分析。结果 不同类型斑块对整体血流流动影响不大,但是脂质斑块病变处的壁面剪切应力低于其余斑块;以增厚斑块作为对照,斑块出现会抑制动脉的扩张,其中脂质斑块最为明显;钙化斑块有最高的平均结构应力,相反脂质斑块平均结构应力则是最低。结论 本文所提出的计算方法能够同时对流体和固体区域进行分析。研究结果有助于更好理解不同斑块类型对于颈动脉病变处的影响。Objective To propose a two-way fluid-structure interaction(FSI) method based on real patients with carotid artery stenosis,and analyze the hemodynamic parameters of carotid plaques with different types at the lesion as well as deformation and stress changes of the plaque itself.Methods Three-dimensional(3D) modeling was performed based on computed tomography angiography(CTA) data of patients with moderate carotid artery stenosis.The carotid artery wall model and plaque model were separated,and transient fluid-structure coupling calculation was performed.The situation from early stage of carotid atherosclerosis to formation of the plaque was simulated.The plaque types were divided into thickened plaques,lipid plaques,mixed plaques and calcified plaques,among which thickened plaques were regarded as non-plaque conditions for representing the thickening of vascular intima-media.The stenotic carotid arteries with different plaque types were compared and analyzed.Results The plaques with different types had little effect on the overall blood flow,but the wall shear stress of lipid plaques at the lesion was lower than that of other plaques.With thickened plaques as a control,concurrence of the plaque would inhibit artery expansion,and lipid plaques were the most obvious.Calcified plaques had the highest average plaque structure stress,while lipid plaques had the lowest average plaque structure stress.Conclusions The method proposed in this study can analyze fluid area and solid area at the same time.The results can contribute to better understanding the influence of different plaque types on carotid artery diseases.

关 键 词：流固耦合 颈动脉斑块 壁面剪切应力 血流动力学 

分 类 号：R318.01[医药卫生—生物医学工程]